Results 201 to 210 of about 1,353,967 (265)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Analyzing Gait Dynamics and Recovery Trajectory in Lower Extremity Fractures Using Linear Mixed Models and Gait Analysis Variables. [PDF]

Bioengineering (Basel)
Rezapour M, Seymour RB, Medda S, Sims SH, Karunakar MA, Habet N, Gurcan MN.   +6 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Differential gene expression analysis of spatial transcriptomic experiments using spatial mixed models. [PDF]

Sci Rep
Ospina OE, Soupir AC, Manjarres-Betancur R, Gonzalez-Calderon G, Yu X, Fridley BL.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Investigating Stress and Coping Behaviors in African Green Monkeys (<i>Chlorocebus aethiops sabaeus</i>) Through Machine Learning and Multivariate Generalized Linear Mixed Models. [PDF]

Vet Sci
Roman B, Gallagher C, Beierschmitt A, Hooper S.   +3 more
europepmc   +1 more source

Genetic divergence and truncation and simultaneous selection in inbred families (S₁) of elephant grass for bioenergetic purposes via mixed models. [PDF]

Sci Rep
Ambrósio M, Daher RF, Silva Santana JG, Leite CL, Duarte JVB, Vidal AKF, Nascimento MR, de Souza AG, Freitas RS, Stida WF, Farias JEC, Santos RM.   +11 more
europepmc   +1 more source

Understanding Learning from EEG Data: Combining Machine Learning and Feature Engineering Based on Hidden Markov Models and Mixed Models. [PDF]

Neuroinformatics
Palma GR, Thornberry C, Commins S, Moral RA.   +3 more
europepmc   +1 more source

Choice of Link Functions for Generalized Linear Mixed Models in Meta-Analyses of Proportions. [PDF]

Res Methods Med Health Sci
Siegel LK, Silva M, Lin L, Chen Y, Liu YL, Chu H.   +5 more
europepmc   +1 more source