Results 21 to 30 of about 1,026,980 (246)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Minimization of multi-penalty functionals by alternating iterative thresholding and optimal parameter choices [PDF]
, 2014 Inspired by several recent developments in regularization theory, optimization, and signal processing, we present and analyze a numerical approach to multi-penalty regularization in spaces of sparsely represented functions.
Naumova, Valeriya, Peter, Steffen
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Mixed-Noise Band Selection for Hyperspectral Images [PDF]
IEEE Access, 2020 Hyperspectral images (HSIs) with abundant spectral information are generally susceptible to various types of noise, such as Gaussian noise and stripe noise. Recently, a few quality-based selection algorithms have been proposed to remove noise bands from HSIs.
Zhen Li, Chenwei Deng, Yun Huang
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Optimized kernel minimum noise fraction transformation for hyperspectral image classification [PDF]
, 2017 This paper presents an optimized kernel minimum noise fraction transformation (OKMNF) for feature extraction of hyperspectral imagery. The proposed approach is based on the kernel minimum noise fraction (KMNF) transformation, which is a nonlinear ...
Gao, Lianru +4 more
core +2 more sources
Mixed-State Topological Order under Coherent Noise
PRX QuantumMixed-state phases of matter under local decoherence have recently garnered significant attention due to the ubiquitous presence of noise in current quantum processors. One of the key issues is understanding how topological quantum memory is affected by realistic coherent noise, such as random rotation noise and amplitude-damping noise.
Seunghun Lee, Eun-Gook Moon
openaire +2 more sources
Noise-induced mixing and multimodality in reaction networks [PDF]
European Journal of Applied Mathematics, 2018 We analyse a class of chemical reaction networks under mass-action kinetics involving multiple time scales, whose deterministic and stochastic models display qualitative differences. The networks are inspired by gene-regulatory networks and consist of a slow subnetwork, describing conversions among the different gene states, and fast subnetworks ...
Plesa, T, Erban, R, Othmer, H
openaire +4 more sources
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source