Results 31 to 40 of about 1,026,980 (246)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Mixed Noise Removal with Pareto Prior
, 2020 Denoising images contaminated by the mixture of additive white Gaussian noise (AWGN) and impulse noise (IN) is an essential but challenging problem. The presence of impulsive disturbances inevitably affects the distribution of noises and thus largely degrades the performance of traditional AWGN denoisers.
Liu, Zhou +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Visibility bound caused by a distinguishable noise particle
, 2011 We investigate how distinguishability of a "noise" particle degrades interference of the "signal" particle. The signal, represented by an equatorial state of a photonic qubit, is mixed with noise, represented by another photonic qubit, via linear ...
Jan Soubusta +5 more
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
LMI approach to mixed performance objective controllers: application to Robust ℋ2 Synthesis [PDF]
, 1995 The problem of synthesizing a controller for plants subject to arbitrary, finite energy disturbances and white noise disturbances via Linear Matrix Inequalities (LMIs) is presented. This is achieved by considering white noise disturbances as belonging to
D'Andrea, Raffaello
core
Characterizing mixed mode oscillations shaped by noise and bifurcation structure
, 2010 Many neuronal systems and models display a certain class of mixed mode oscillations (MMOs) consisting of periods of small amplitude oscillations interspersed with spikes.
Juan Luis Cabrera +6 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source