Results 91 to 100 of about 9,122 (305)

Design of nonflammable mixed refrigerants based on the partial molar enthalpy difference in mixed-refrigerant Joule-Thomson refrigerators with/no pre-cooling stage

IOP Conference Series: Materials Science and Engineering
Abstract Mixed-refrigerant Joule-Thomson refrigeration (MJTR) is an important cooling method at temperatures from 80 to 230 K. It can be used in cryosurgery, high-temperature superconductivity and sensor cooling etc. However, most of the studies are on nitrogen-hydrocarbon refrigerants, which are not allowed in applications where there ...
Yunxiao Wang, Yanxing Zhao, Yuwei Sun, Haocheng Wang, Maoqiong Gong   +4 more
openaire   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

A Novel Approach of −80 °C Cascade Refrigeration System Using Non-Flammable Quaternary Refrigerants for Semiconductor Process Applications

Energies
Ultra-low temperature chillers have seen increasing demand with the advancement of semiconductor technology. Mixed refrigerant (MR) cascade refrigeration systems (CRSs) are widely utilized for their stability and high cooling performance at low ...
Su-Been Lee, Chang-Hyo Son, Joon-Hyuk Lee   +2 more
doaj   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Investigation of Inlet Guide Vane Efficiency in Centrifugal Compressors for the Turbo Refrigeration Machines [PDF]

Problems of the Regional Energetics
The article investigates the influence of geometric parameters of inlet guide vanes (IGVs), including blade profiling and design features, on their operational efficiency.
Danilishin A.M., Kozhukhov Y. V., Fateeva E.S., Aksenov A.A.   +3 more
doaj   +1 more source

Climate-friendly technologies in the mobile air-conditioning sector: A patent citation analysis [PDF]

The development of climate-friendly technologies and its diffusion across countries is of key importance to slow climate change. This paper considers technologies in the mobile air-conditioning (MAC) sector which is a major contributor of ...
Frank Goetzke, Tilmann Rave
core  

An integrated mixed refrigeration cycle for pre-cooling of refrigeration below 25 K

IOP Conference Series: Materials Science and Engineering, 2019
Two trends can be found in current large-scale cryogenic projects. The first is the ever-increasing capacity requirements, while also a shift towards cooling demands at higher temperatures is observed. Conventional helium cycles require the use of oil flooded screw compressors, which are limited in efficiency, capacity, and reliability. Reverse-Brayton
S Kloeppel, H Quack, C Haberstroh
openaire   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source