Results 201 to 210 of about 7,094,748 (296)

Toward a mixed-methods framework for evaluating digital health systems in low-resource settings: an infrastructure-aware perspective. [PDF]

Front Digit Health
Nyatuka RD, Cherinet P, Jabin MSR.
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Reaching zero-dose children in conflict-affected and fragile settings in the WHO African Region: a scoping review of strategies and evidence gaps. [PDF]

BMJ Public Health
Iwu-Jaja C, Olu OO, Iwu CD, Nyasulu P, Wiysonge CS.   +4 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Facilitators, barriers, and interventions for exercise adherence in patients with prediabetes: a mixed-methods systematic review. [PDF]

Ther Adv Endocrinol Metab
Yuan Y, Deng M, Chen H, Lu X, Chen X, Bai D, Gao H, Hou C, Gao J.   +8 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

School administrator perspectives on electronic nicotine delivery systems use in Montana schools: A mixed-methods study. [PDF]

Tob Prev Cessat
Powell S, Fuller S, Spence T, Richidt L, Aune N.   +4 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

A Narrative Review of Implant Density and Surgical Outcomes in Adolescent Idiopathic Scoliosis. [PDF]

Cureus
Shobode MA, Bafor A, Rajjoub R, Tulchin-Francis K, Chambers RC, Kadado A.   +5 more
europepmc   +1 more source