Results 131 to 140 of about 9,830,689 (286)
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Oscillations of differential equations of mixed type
, 2015 We develop oscillatory results for the n-th order (n\(\geq 1)\) differential equations of the retarded \[ y^{(n)}(t)+(- 1)^{n+1}\sum^{k}_{i=1}p_ i^ ny(t-n\tau_ i)=0 \] and the advanced type \[ y^{(n)}(t)-\sum^{\ell}_{j=1}q_ j^ ny(t+n\sigma_ j)=0 \] where \(p_ i,\tau_ i\), \(i=1,2,...,k\) and \(q_ j\), \(\sigma_ j,j=1,2,...,\ell\) are positive constants,
Ladas, G., Stavroulakis, I. P.
openaire +2 more sources
A BPE model for the Burgers' equation [PDF]
We study the BPE (Brownian particle equation) model of the Burgers equation presented in the preceeding article [6]. More precisely, we are interested in establishing the existence and uniqueness properties of solutions using probabilistic techniques ...
Arturo Kohatsu, Shigeyoshi Ogawa
core
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Fuzzy Stability of Generalized Mixed Type Cubic, Quadratic, and Additive Functional Equation
Journal of Inequalities and Applications, 2011 In this paper, we prove the generalized Hyers-Ulam stability of generalized mixed type cubic, quadratic, and additive functional equation, in fuzzy Banach spaces. 2010 Mathematics Subject Classification: 39B82; 39B52.
Shin Dong +4 more
doaj
TRICOMI'S PROBLEM FOR A MIXED-TYPE EQUATION.
Tricomi's problem for a mixed type equation is presented, the uniqueness of the solutions of the described problems is proved based on the extremum principle, works after Tricomi and their solutions are discussed.
Chorieva, S.T +2 more
openaire +2 more sources
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source