Results 131 to 140 of about 6,390,979 (296)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Evaluating the challenges and impacts of mixed-use neighborhoods on urban planning: an empirical study of a megacity, Karachi, Pakistan

Discover Sustainability
Introduction Modern development is patented by rapid urbanization, which largely negatively affects the quality of life. Over the past few decades in the World; in the field of urban planning and the real estate market, Mixed-use development has become a
Anila Kausar, Salman Zubair, Hadeeqa Sohail, Muhammad Mushahid Anwar, Asad Aziz, Sergij Vambol, Viola Vambol, Nadeem A. Khan, Serhii Poteriaiko, Vasyl Tyshchenko, Rustam Murasov, Fizza Ejaz, Owais Iqbal Khan   +12 more
doaj   +1 more source

Predicting Parasite Dynamics in Mixed-Use Trans-Himalayan Pastures to Underpin Management of Cross-Transmission Between Livestock and Bharal. [PDF]

Front Vet Sci, 2021
Khanyari M, Suryawanshi KR, Milner-Gulland EJ, Dickinson E, Khara A, Rana RS, Rose Vineer H, Morgan ER.   +7 more
europepmc   +1 more source

Mixing of Land-use

Studies in Regional Science, 1976
The remarkable aspect of urbanization in Japan is the rapid change of landuse, which is due to enlarging of urbanized area and renewing of city. The development of such change is almost never planned and is not uniformly and continuously carried out.
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Current state of mental health and substance use in Toledo, Belize: A mixed methods study

Cambridge Prisms: Global Mental Health
Mental health and substance use are increasingly pressing issues in communities across low-and-middle income countries, including Belize, particularly Toledo, the country’s most rural and resource-limited district.
Jaclyn Kirsch, Megan Fabbri, Kristen Kerr, Lynette Gomez   +3 more
doaj   +1 more source

Human Fecal Pollution Monitoring and Microbial Risk Assessment for Water Reuse Potential in a Coastal Industrial-Residential Mixed-Use Watershed. [PDF]

Front Microbiol, 2021
Kongprajug A, Denpetkul T, Chyerochana N, Mongkolsuk S, Sirikanchana K.   +4 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Monitoring Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) Levels in Mixed-Use Residential-Commercial Buildings in Shiraz, Iran: Assessing the Carcinogenicity and Non-Carcinogenicity Risk of Their Inhabitants. [PDF]

Int J Environ Res Public Health, 2022
Baberi Z, Azhdarpoor A, Hoseini M, Baghapour M, Derakhshan Z, Giannakis S.   +5 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source