Results 151 to 160 of about 986,782 (318)

A numerical investigation of the compressible mixing layer

open access: yes, 1989
The effect of Mach number on the plane muong layer has been investigated by means of linear stability theory and two- and three-dimensional direct numerical simulations of the compressible Navier-Stokes equations.
Sandham, N.D.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Mixing sets linked by bidirected paths [PDF]

open access: yes
Recently there has been considerable research on simple mixed-integer sets, called mixing sets, and closely related sets arising in uncapacitated and constant capacity lot- sizing.
DI SUMMA, Marco, WOLSEY, Laurence
core  

Macro-instabilities of a Suspension in an Axially Agitated Mixing Tank

open access: yesActa Polytechnica, 2002
This paper deals with an experimental assessment of the occurrence of flow macro-instabilities in a mechanically stirred suspension and visual observation of the origination and extinction of macro-vortices.
M. Jahoda   +3 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Chain-branching explosions in mixing layers

open access: yes, 1999
The chain-branching process leading to ignition in the high-temperature hydrogen-oxygen mixing layer is studied by application of a novel WKB-like method when, as is typically the case, two branching radicals cannot be assumed to maintain steady state ...
Williams, F.A.   +2 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The Impact of Mixing and Ca(OH)2 Suspension Concentration on Hydroxyapatite Synthesis

open access: yes
The effects of lime concentration together with mixing conditions on synthesis of hydroxyapatite is being ...
Sokolova, Marina   +2 more
core  

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