Results 51 to 60 of about 1,142,402 (245)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Numerical Modelling of Horizontal Oil-Water Pipe Flow
Energies, 2020 The purpose of this work is modeling of a horizontal oil–water flow with and without the Algebraic Interfacial Area Density (AIAD) model. Software and hardware developments in the past years have significantly increased and improved the accuracy ...
Thomas Höhne +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Unsteady behaviour of opposite impinging jets interaction in crossflow
Nihon Kikai Gakkai ronbunshu, 2016 A mixing of fuel with air in jet engine is studied by analyzing unsteady turbulent flow in a simplified flow channel which consists of the opposed jets in a cross-flow.
Takahisa NAGAO, A.Koichi HAYASHI
doaj +1 more source
The Influence of Inflow Swirl on Cavitating and Mixing Processes in a Venturi Tube
Fluids, 2020 A study of the mixing flows (Schmidt number = 103) in a cavitating Venturi tube that feature linear and swirling flows is presented in this paper. The Large Eddy Simulation (LES) turbulence model, the Schnerr–Sauer cavitation model, and the mixture ...
Hongbo Shi, Petr Nikrityuk
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Turbulent mixing at a stable density interface : the variation of the buoyancy flux–gradient relation [PDF]
, 2007 Experiments conducted on mixing across a stable density interface in a turbulent Taylor–Couette flow show, for the first time, experimental evidence of an increase in mixing efficiency at large Richardson numbers.
Flor, J. -B. +2 more
core +1 more source
Fluids, 2020 Here we consider the effects of surface buoyancy flux and wind stress on a front in turbulent thermal wind (TTW) balance using the framework of Crowe and Taylor (2018).
Matthew N. Crowe, John R. Taylor
doaj +1 more source