Results 131 to 140 of about 865,428 (296)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Unsteady Modelling of the Mixing Efficiency, Species Transport, and Flow Structure in a Novel Photochemical Reactor

Fluids
This paper deals with computational fluid dynamics (CFD) to improve the design of a new scalable photochemical reactor which uses the Taylor–Couette flow principle.
Zakaria Mansouri, Richard Jefferson-Loveday, Stephen J. Pickering, Michael W. George   +3 more
doaj   +1 more source

Mixing Efficiencies in Patchy Turbulence

Journal of Physical Oceanography, 2002
Abstract The efficiency of mixing in stably stratified systems where the turbulent mixing is confined to intermittent patches is investigated theoretically. It is possible to define two different flux Richardson numbers for mixing in such a system.
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

kh2d-solver: A Python library for idealized two-dimensional incompressible Kelvin-Helmholtz instability

Applied and Computational Mechanics
This study presents an open-source Python library for simulating two-dimensional incompressible Kelvin-Helmholtz (KH) instabilities in stratified shear flows.
Herho S. H. S., Trilaksono N. J., Fajary F. R., Napitupulu G., Anwar I. P., Khadami F., Irawan D. E.   +6 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

An Efficient Mix-Net

, 2002
We describe an efficient mix-net. Its efficiency is based on a novel method, double encryption. We use a variant of "repetitive robustness", introduced by Jakobsson, to achieve robustness. The notion of double encryption enables us to avoid the large number of proofs of knowledge required in most mix-net constructions.
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Mixing Enhancement of Electroosmotic Flow in Microchannels under DC and AC Electric Field

Journal of Applied Fluid Mechanics, 2020
A novel micromixer is presented in this study and the effect of DC or AC electric field on mixing efficiency is investigated numerically. Four types of AC waveforms are considered to explore the flow characteristic and mixing efficiency.
S. Dong, P. F. Geng, D. Dong, C. X. Li
doaj