Results 111 to 120 of about 699,277 (302)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Photon Pair Generation with Tailored Frequency Correlations in Graded-Index Multimode Optical Fibers

, 2017
We study theoretically the generation of photon pairs with controlled spectral correlations via the four-wave mixing (FWM) process in graded-index multimode optical fibers (GIMFs).
Mafi, Arash, Pourbeyram, Hamed
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Deep Mixing and Metallicity: Carbon Depletion in Globular Cluster Giants

, 2008
We present the results of an observational study of the efficiency of deep mixing in globular cluster red giants as a function of stellar metallicity. We determine [C/Fe] abundances based on low-resolution spectra taken with the Kast spectrograph on the ...
Barbon, Bell, Briley, Cassisi, Cassisi, Cavallo, Chanamé, Charbonnel, Charbonnel, Charbonnel, Demarque, Denissenkov, Denissenkov, Eggleton, Fusi Pecci, Graeme H. Smith, Gratton, Gustafsson, Lee, Michael M. Briley, Sarah L. Martell, Smith, Weiss, Zoccali   +23 more
core   +1 more source

[Case-mix index and length of hospitalization].

Il Giornale di chirurgia, 2010
The ACG (Adjusted Clinical Groups) case-mix system is a classification method of diseases of patients, focused on the person. Depending on the pattern of these morbid conditions, the ACG system assigns each patient to a single group (an ACG group), which allows to capture the effects of a group of diseases in estimates of resource use.
D'ANDREA, Vito, CATANIA, Antonio, DI MATTEO, Filippo Maria, SAVINO, GRAZIA, R. Greco, DI MARCO, CARLO, DE ANTONI, Enrico   +6 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Numerical analysis of rotational speed impact on mixing process in a horizontal twin-shaft paddle batch mixer with non-Newtonian fluid [PDF]

FME Transactions, 2016
Nowadays, the priority of food industry processes is based on mixing of the various flavour pastes with the air. Optimal mixing process in the results means the instantaneous preparation of the homogenous and easily spreadable paste while consuming the ...
Kozić Mirko S., Ristić Slavica S., Linić Suzana Lj., Hil Toni, Stetić-Kozić Srđa   +4 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Prediction of Equilibrium Mixing Index and Optimum Mixing Time for Three solid materials in Fluidized Column

Al-Khawarizmi Engineering Journal, 2010
Equilibrium and rate of mixing of free flowing solid materials are found using gas fluidized bed. The solid materials were sand (size 0.7 mm), sugar (size0.7 mm) and 15% cast iron used as a tracer.
Abbas H. Sulaymon, Ammar S. Abbas, Rasha H. Salman   +2 more
doaj   +2 more sources