Results 161 to 170 of about 706,749 (345)

Nonparametric Estimation of Copulas for Time Series [PDF]

We consider a nonparametric method to estimate copulas, i.e. functions linking joint distributions to their univariate margins. We derive the asymptotic properties of kernel estimators of copulas and their derivatives in the context of a multivariate ...
Jean-David FERMANIAN, Olivier SCAILLET
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Investigation of mixing performance in electro-osmotic micromixers through rigid baffle design and parameter optimization

Scientific Reports
Electro-osmotic micromixers constitute a specialized class of active micromixers that apply alternating current (AC) to electrodes. This methodology promotes the formation of vortical structures within the fluid medium, resulting in a substantial ...
Ali Khoshnod, Reza Shahsavandi, Khashayar Hosseinzadeh   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Optimization of passive micromixers: effects of pillar configuration and gaps on mixing efficiency

Scientific Reports
Chemical bioreactions play a significant role in many of the microfluidic devices, and their applications in biomedical science have seen substantial growth.
Ali Kheirkhah Barzoki
doaj   +1 more source

Upper atmosphere dynamics [PDF]

The spatial distribution of stratospheric ozone is useful in diagnosis of some features of the large scale atmospheric circulation, and the ozone may also interact with the atmospheric general circulation.
Miller, Timothy L., Reynolds, Nathaniel D.   +1 more
core   +1 more source

Estimation of mixing index and contact number by coordination number sampling in an incompletely mixed state.

, 1987
Hisakazu Shindo
openalex   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A real-time mix-adjusted median property price index enabled by an efficient nearest neighbour approximation data structure [PDF]

, 2022
Robert Miller, Phil Maguire
openalex   +1 more source