Results 111 to 120 of about 880,405 (266)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
, 2017 A short time ago we were asked whether any injustice would result to either creamery-man or patron, if the latter should set his evening’s milk, skim it in the morning, mix the cream with the morning’s milk and send the mixture to the creamery instead of
Leighton, F., Wallace, H.
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, 2012 The ultimate goals of this study included investigation of the optimal ranges for paste content, amount of cementations materials and aggregate gradation for concrete paving mixtures.
Rudy, Adam, Olek, Jan
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 1957 In this study a self-fed, urea-molasses mixture is being compared to molasses self-fed plus 1.3 pounds of soybean meal in an effort to determine if a urea-molasses mixture self-fed on dry grass will serve as an adequate source of protein and energy ...
Cox, R.F. +3 more
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Feshbach spectroscopy of an ultracold Rb-Cs mixture [PDF]
, 2012 This thesis reports the observation of interspecies Feshbach resonances in an ultracold mixture of Rb and Cs atoms. A versatile combined magnetic and optical potential has been designed and constructed which is capable of bringing both $^{87}\rm{Rb}$ and
Jenkin, Daniel Lester +2 more
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