Results 181 to 190 of about 3,472,659 (303)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Predictors of Variation in the Cognitive Function Trajectories among Older Adults Living Alone: A Growth Mixture Modeling Approach. [PDF]

Healthcare (Basel), 2023
Park S, Lee S, Jeong KH.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The No-U-Turn sampler and its mixture-modeling revision for the 4-parameter normal ogive model. [PDF]

Front Psychol
Guo S, Sun Q, Li X.
europepmc   +1 more source

Gaussian mixture modeling of acceleration-derived signal for monitoring external physical load of tennis player. [PDF]

Front Physiol, 2023
Marutani Y, Konda S, Ogasawara I, Yamasaki K, Yokoyama T, Maeshima E, Nakata K.   +6 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Longitudinal trajectories and predictive factors of depressive symptomatology in Chinese elderly with hearing loss: a growth mixture modeling analysis. [PDF]

BMC Geriatr
Wen K, Li E, Ai F, Tang P, Wen H, Guo B.
europepmc   +1 more source

Mixture-modeling approach reveals global and local processes in visual crowding. [PDF]

Sci Rep, 2022
Jimenez M, Kimchi R, Yashar A.
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A systematic review and meta-analysis of cross-sectional mixture modeling applications to identify person-centered phenotypes of posttraumatic stress disorder. [PDF]

Clin Psychol Rev
Pugach CP, Bovin MJ, Contractor AA, Wisco BE, Pietrzak RH, Marx BP, Adams SW.   +6 more
europepmc   +1 more source