G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran +11 more
wiley +1 more source
Mobile Apps for HIV and Sexually Transmitted Infection Prevention in Canada, Mexico, and the United States: Environmental Scan. [PDF]
Fernández-Sánchez H +6 more
europepmc +1 more source
Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi +3 more
wiley +1 more source
A Functional Joint Model for Survival and Multivariate Sparse Functional Data in Multi-Cohort Alzheimer's Disease Study. [PDF]
Wang W +4 more
europepmc +1 more source
PolyGraph, a flexible graphene‐polycaprolactone nanocomposite, unites conductivity, biocompatibility, and processability for next‐generation neural interfaces. Fabricated into microneedle arrays with ultra‐flexible backings, PolyGraph enables bidirectional neuronal recording and stimulation in brain tissue, advancing brain‐computer interface (BCI) and ...
Jack Maughan +12 more
wiley +1 more source
MRI and histopathology of primary extranodal spinal cord T-cell-rich B-cell lymphoma in a cat. [PDF]
Mann O +4 more
europepmc +1 more source
Why raw yield data are better than relative yield in informing agronomic and economic decisions
Abstract While relative yield is widely used for its comparability, normalization can cause significant information loss. This study reframes yield metric selection as a model evaluation problem to determine the most accurate representation of crop response. We evaluated seven yield metrics with three agronomic models, comparing estimates of a critical
Falin Sun +4 more
wiley +1 more source
Enhancing artificial intelligence-driven sleep apnea diagnosis: The critical importance of input signal proficiency with a focus on mandibular jaw movements. [PDF]
Martinot JB +3 more
europepmc +1 more source
Soil health as nonequilibrium flow: Bridging a persistent conceptual‐to‐computational inconsistency
Abstract Soil health concepts emphasize soil aggregation and structure as central indicators of healthy, functioning soils, yet this emphasis carries an implicit acknowledgment rarely made explicit in models: aggregated soils exhibit nonequilibrium water flow behaviors through preferential pathways.
Aaron Lee M. Daigh +7 more
wiley +1 more source

