Results 41 to 50 of about 8,744,702 (255)

Towards a Theory of Representation Learning for Reinforcement Learning

open access: yes, 2021
Presented online via Bluejeans Events on September 15, 2021 at 12:15 p.m.Alekh Agarwal is a researcher who works on theoretical foundations of machine learning, spanning many areas including large-scale and distributed optimization, high-dimensional ...
Agarwal, Alekh
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Large language model-assisted multi-objective optimization for an integrated multimodal e-mobility platform

open access: yesTransportation Research Interdisciplinary Perspectives
As urban transportation evolves, shared e-mobility is increasingly recognized as a socio-technical system shaping urban equity, social inclusion, and mobility behaviour.
Yue Ding   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Hydro-power generation forecast in South Africa based on Machine Learning (ML) models

open access: yesScientific African, 2023
With the advancement of technology and the ever-growing need for electronics, electricity has become an indispensable aspect of modern life. Developing or underdeveloped nations must overcome a number of obstacles to balance the supply and demand for ...
Selaki Ivy Ramarope   +2 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Structured Prediction - Beyond Support Vector Machine and Cross Entropy

open access: yes, 2021
Presented online via Bluejeans Events on September 29, 2021 at 12:15 p.m.Francis Bach is a researcher at INRIA in the Computer Science department of Ecole Normale Supérieure, in Paris, France.
Bach, Francis
core   +1 more source

LIVER CANCER PREDICTION USING MACHINE LEARNING (ML) MODELS

open access: yesШәкәрім университетінің хабаршысы: Техника ғылымдар
A comparative evaluation of machine learning models for predicting liver cancer risk was performed using an open structured clinical dataset. A Kaggle dataset was used in the study (N=5000): target variable Liver_cancer, 13 features (9 numerical, 4 ...
I. B. Karymsakova   +4 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

open access: yesMolecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński   +12 more
wiley   +1 more source

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