Results 41 to 50 of about 15,978 (252)
Complete Correction of Brain and Spinal Cord Pathology in Metachromatic Leukodystrophy Mice
Frontiers in Molecular Neuroscience, 2021 Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder characterized by accumulation of sulfatides in both glial cells and neurons. MLD results from an inherited deficiency of arylsulfatase A (ARSA) and myelin degeneration in the central and ...
Emilie Audouard +6 more
doaj +1 more source
Infantile Metachromatic Leukodystrophy (MLD): A Rare Case
Cureus, 2022 Metachromatic leukodystrophy (MLD) is the typical white matter disease belonging to the lysosomal sphingolipid storage group and is a genetic autosomal recessive disorder. Early presentation is in the form of learning disability and behavioral issues; the subsequent involvement is gait and balance.
Gajbhiye, Varsha +2 more
openaire +2 more sources
A Soft Robotic Device for Targeted Massage Therapy of Residual Limbs
Advanced Robotics Research, EarlyView.Residual limb edema after amputation can hinder recovery and delay prosthetic fitting. This study presents a soft‐robotic wearable device that delivers sequential compression through pneumatic McKibben actuators. By replicating the principles of manual lymphatic drainage, the device generates controlled mechanotherapeutic pressure patterns, providing a
Maria Grazia Polizzotto +5 more
wiley +1 more source
Neural Correlates of Masking Level Differences: Evidence From Auditory Brainstem Responses
Brain and BehaviorObjective: This study aimed to investigate the neural correlates of masking level differences (MLD) by examining their relationship with auditory brainstem responses (ABR) in normal‐hearing adults, to better elucidate the underlying brainstem mechanisms ...
Aysenur Aykul Yagcioglu +2 more
doaj +1 more source
Phenotypic variation between siblings with Metachromatic Leukodystrophy
Orphanet Journal of Rare Diseases, 2019 Background Metachromatic Leukodystrophy (MLD) is a rare autosomal-recessive lysosomal storage disorder caused by mutations in the ARSA gene. While interventional trials often use untreated siblings as controls, the genotype-phenotype correlation is only ...
Saskia Elgün +10 more
doaj +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Highly Stabilized Ni‐Rich Cathodes Enabled by Artificially Reversing Naturally‐Formed Interface
Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.The application of Ni‐rich cathode materials is obstructed by interfacial and structural instability. This work proposes a facile and cost‐effective Al‐based vapor‐phase surface reaction strategy on Ni‐rich cathode to maintain its structural integrity from near‐surface to bulk.
Jinjin Ma +11 more
wiley +1 more source
Masker bandwidth and the MLD [PDF]
The Journal of the Acoustical Society of America, 1983 Thresholds for binaurally in-phase (SO) and out-of-phase (Sπ) tones masked by diotic noise were measured as a function of noise bandwidth at 250 and 4000 Hz. Results show that the familiar dependence of the MLD for a tone in wideband noise on the frequency of the tone derives primarily from the dependence of critical bandwidth on frequency and only ...
P. M. Zurek +3 more
openaire +1 more source
Media Attention to Climate Change and Investor Flows in US Equity Mutual Funds
Business Strategy and the Environment, EarlyView.ABSTRACT This paper investigates how climate‐related news influences mutual fund investor behaviour in the United States. Although prior research has documented the financial relevance of climate risks, little is known about how media attention to climate change shapes capital allocation across mutual funds.
Laura Andreu +3 more
wiley +1 more source
Ecography, EarlyView.Correlative species distribution models (SDMs) are quantitative tools in biogeography and macroecology. Building upon the ecological niche concept, they correlate environmental covariates to species presence to model habitat suitability and predict species distributions.
Moritz Klaassen +3 more
wiley +1 more source