Results 71 to 80 of about 32,374 (267)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Brine shrimp lethality and phytochemical determination of aqueous extracts of Senna singueana, Musa paradisiaca, and Ziziphus mucronata in Malawi.

Journal of Basic and Applied Research in Biomedicine, 2015
Traditional medicine is still practiced in different parts of the world; with traditional healers as powerful and important members of the society. Senna singueana, Musa paradisiaca, and Ziziphus mucronata plants are commonly used by traditional healers
Isaac Shawa, John Mponda, Chisomo Msefula, Happy Manda, Mavuto Gondwe, Cecilia Maliwichi-Nyirenda   +5 more
doaj   +2 more sources

Innovative Precision Pruning Strategies Targeting Medium-length Fruiting Shoots to Manage Return Bloom and Enhance Shoot Quality in Apple

HortTechnology
This study evaluates two innovative shoot-level interventions targeting medium-length shoots (MLS) in apple. Experiments were conducted on two apple cultivars, Amasya and Golden Reinders, grafted onto M.9 rootstock, to assess how heading cuts applied to ...
Ersin Atay
doaj   +1 more source

ML(n)BiCGStabt: A ML(n)BiCGStab Variant with A-transpose [PDF]

2012 Fourth International Conference on Computational and Information Sciences, 2012
The 1980 IDR method plays an important role in the history of Krylov subspace methods. It started the research of transpose-free Krylov subspace methods. In this paper, we make a first attempt to bring back A-transpose to the research area by presenting a new ML(n)BiCGStab variant that involves A-transpose in its implementation. Comparisons of this new
openaire   +3 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Error Distribution Pattern Analysis of Mobile Laser Scanners for Precise As-Built BIM Generation

Applied Sciences
Point clouds acquired by mobile laser scanners (MLS) are widely used for generating as-built building information models (BIM), particularly in indoor construction environments and existing buildings.
Sung-Jae Bae, Junbeom Park, Joonhee Ham, Minji Song, Jung-Yeol Kim   +4 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source