Results 181 to 190 of about 3,296,150 (267)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Cost-effectiveness of amyloid-targeting therapies in a memory clinic population; a simulation study

van der Veere P, Broulikova H, Handels R, Teunissen C, Collij L, Vijverberg E, van der Flier W, Berkhof J.   +7 more
europepmc   +1 more source

Harmonized Dual Deep Learning Architectures for Image-Based Diagnostics of Skin Neglected Tropical Diseases: Benchmark Study via Novel Funnel Framework. [PDF]

JMIR Dermatol
Minyilu Y, Yimer MA, Meshesha M.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Variations of global brain asymmetry are associated with aging and related diseases. [PDF]

Sci Adv
Hu H, Guo D, Pu Y, Abuduaini Y, Wang X, Francks C, Thompson PM, Kong XZ.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A frontal cortical world model shapes inference of causal relationships in hippocampus

Luo S, Li M, Pan D, Kingston N, Klein-Flügge M, Mahmoodi A, Rushworth M.   +6 more
europepmc   +1 more source

Effective-Component Compatibility of Bufei Yishen Formula Alleviates Alveolar Epithelial Barrier Damage in COPD Through Inhibition of p38 MAPK Phosphorylation. [PDF]

Int J Chron Obstruct Pulmon Dis
Shao X, Zhang L, Guo M, Wang C, Chu H, Mo Y, Lu R, Zhao P, Tian Y.   +8 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Low concentrations of tetrasodium EDTA cause significant killing of biofilm-associated Pseudomonas aeruginosa in high-validity models of chronic wound and cystic fibrosis lung infections - but not in a model of endotracheal tube colonization. [PDF]

Access Microbiol
Orababa OQ, Cornbill C, Kade A, Reddy N, Gulati R, Harrison F.   +5 more
europepmc   +1 more source