Results 111 to 120 of about 6,225,982 (226)

Fr. Anthony Cotta, MM, with Bicycle

Fr. Anthony Cotta, MM, with his bicycle. China. B/W Lantern Slide. ca.
Cotta, MM, Rev. Anthony
core   +1 more source

An Innovative, Pilot Program to Enhance Career Development and Staff Engagement for Mid- and Late-Career Physician Staff Within an Academic Institution: The RISE Program

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2020
Anjali Bhagra, MD, Ivana T. Croghan, PhD, Tammy R. Monson, MA, Anne A. Schletty, Laurie K. Baedke, MHA, Karthik Ghosh, MD   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Diagnostic Imaging Analysis of Humerus Bone Structure in Long-Legged Buzzard (Buteo rufinus): Radiology and CT-Scan Insights. [PDF]

Vet Med Sci
Alinejad N, Esmailinejad MR, Shafiei H, Jahedi M.   +3 more
europepmc   +1 more source

Indagine sperimentale sul comportamento di pareti sismiche in acciaio sottoposte a taglio

, 2005
The paper concerns the experimental results performed on steel (S 235) zinc plated panels having 1500 x 1150 x 1.5 mm dimensions, linked to hinged steel frame.
SACCO MM, LO GIUDICE E., SCIBILIA, Nunzio   +2 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Papain proteolitikus mechanizmusának vizsgálata QM/MM módszerrel

, 2012
A Papain enzim proteolítikus mechanizmusának vizsgálata hibrid kvantummechanikai/molekulamechanikai (QM/MM, ONIOM) módszerrel. A dolgozat tárgya a Papainra jellemző acilezési és dezacilezési mechanizmusok elméleti kémiai módszerekkel történő leírása ...
Fekete, Attila
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source