Results 81 to 90 of about 11,198,539 (258)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Energy of a knot: variational principles; Mm-energy [PDF]
, 2004 Let $E_f$ be the energy of some knot $\tau$ for any $f$ from certain class of functions. The problem is to find knots with extremal values of energy. We discuss the notion of the locally perturbed knot.
Karpenkov, O. N.
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Conceptual modelling and the quality of ontologies: A comparison between object-role modelling and the object paradigm [PDF]
, 2010 Ontologies are key enablers for sharing precise and machine-understandable semantics among different applications and parties. Yet, for ontologies to meet these expectations, their quality must be of a good standard.
Al-Asswad, MM +3 more
core
Atmospheric monitoring in the mm and sub-mm bands for cosmological observations: CASPER2
, 2012 Cosmological observations from ground at millimetre and sub-millimetre wavelengths are affected by atmospheric absorption and consequent emission. The low and high frequency (sky noise) fluctuations of atmospheric performance imply careful observational ...
De Gregori, Simone +4 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Experimental study on long friction-type bolted joint combined with interference fit bolt
Advances in Bridge EngineeringIn recent years, high-strength bolts with friction-type joints have been lengthened to withstand increased traffic load. However, with increase in the joint length, the force able to be resisted by bolted joints has decreased owing to uneven distribution
Yu Chen +4 more
doaj +1 more source