Results 111 to 120 of about 4,442,056 (228)

Liquid Atmospheric Pressure MALDI (LAP-MALDI) Mass Spectrometry: A Versatile Tool for the Characterization of Synthetic Polymers. [PDF]

Rapid Commun Mass Spectrom
Kowalczyk AE, Brown J, Morris M, Cramer R.   +3 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Correction: Superficial temporal artery and branches in thai cadavers: anatomical variations, ethnic considerations, and filler injection safety. [PDF]

Sci Rep
Durongphan A, Chongkolwatana W, Chokdee R, Sutantayawalee P, Sripraditpong N, Wattanaphichet A, Sovikul K, Lumyoungsatien J.   +7 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

An Innovative, Pilot Program to Enhance Career Development and Staff Engagement for Mid- and Late-Career Physician Staff Within an Academic Institution: The RISE Program

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2020
Anjali Bhagra, MD, Ivana T. Croghan, PhD, Tammy R. Monson, MA, Anne A. Schletty, Laurie K. Baedke, MHA, Karthik Ghosh, MD   +5 more
doaj   +1 more source

Photocross-linking activity-based probes to capture the dynamics of ubiquitin RING E3 ligase interactions. [PDF]

Biochem J
Chandler SF, Tatham MH, Branigan E, Nakasone MA, Makukhin N, Ciulli A, Hay RT.   +6 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Deep learning-based CT slice synthesis improves radiomic feature reproducibility and discriminative performance in lung nodule assessment. [PDF]

Insights Imaging
Yang H, Zhang Z, Tian L, Dang P, Wan L, Zhou Z, Li J, Cao L, Yang X, Chen J.   +9 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Electrophysiological Markers in Hypertrophic Cardiomyopathy: Enhancing Sudden Cardiac Death Risk Prediction with Index of Cardiac Electrophysiological Balance and Its Corrected Variant. [PDF]

Anatol J Cardiol
Balaban İ, Tanyeri S, Karaduman A, Kültürsay B, Gültekin Güner E, Keten MF, Efe SÇ, Alizade E.   +7 more
europepmc   +1 more source