Results 41 to 50 of about 4,442,056 (228)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
National Journal of Community MedicineBackground: Informal caregivers of cancer patients often experience reduced self-efficacy, impaired quality of life (QOL), and high caregiving burden. The aim of this study was to evaluate the impact of Comprehensive Caregiver Support on these outcomes.
Diksha sharma +3 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Unitarianism and Pluralism in Peripatetic Political Philosophy [PDF]
سیاست متعالیه, 2017 Unity and plurality is one of the important issues in the history of political philosophy, tendency of political philosopher towards each of which can influence all aspects of his political philosophy.
mahdi ghorbahni, mahdi omidi
doaj
a mm is a mm - the architect as an organizer
, 2021 This is a story about a detail in a system. This is a story about a detail and a city. The greater Reykjavik area is taking a step away from the domination of the private car. The century of mixed transportation has arrived: bicycles, busses, scooters, even with walking, have become a thing in Iceland.
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Basic Knowledge and Practice of Chest Physiotherapy among Healthcare Providers: A Descriptive Cross-sectional Study [PDF]
Indian Journal of Respiratory CareIntroduction: Chest physiotherapy (CPT) is an airway clearance technique intended to improve quality of life and reduce healthcare costs and morbidity. Chest physical therapy is still a neglected practice in respiratory patients.
Arjun Kumar +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source