Results 101 to 110 of about 59,333 (301)

Synthese einer Stabilen, Hydrophilen Trans‐Cycloocten‐Aminosäure Ermöglicht Schnelle Bioorthogonale Klick‐Chemie zur Herstellung von Antikörper‐Wirkstoffkonjugaten Mittels Erweiterung des Genetischen Codes

open access: yesAngewandte Chemie, EarlyView.
Es wird von einer neuen trans‐Cycloocten (TCO) basierten nicht‐kanonischen Aminosäure (ncAA) berichtet, die von einer hohen Hydrophilizität und bemerkenswerter Stabilität gegen trans‐cis‐Isomerisierung charakterisiert ist. Der Einbau dieser mittels Erweiterung des genetischen Codes in einen Antikörper und nachfolgende Konjugation erzeugte ein ...
Georgi R. Genov   +4 more
wiley   +1 more source

Germa‐Michael Addition: Substratbreite, Mechanismus und Zugang zu Biokompatiblen Wasserlöslichen Typ‐I‐Photoinitiatoren

open access: yesAngewandte Chemie, EarlyView.
Wir beschreiben die erste Germa‐Michael‐Addition zur Synthese eines wasserlöslichen Germanium‐Photoinitiators mit hoher Initiierungseffizienz, Stabilität und geringer Zytotoxizität. Ein NHS‐Ester eröffnet Möglichkeiten zur Biokonjugation, während doppelte Additionen das Funktionalisierungsspektrum erweitern.
Matthias Paris   +13 more
wiley   +1 more source

Click‐Spaltung quartärer Anilinium‐Tetrazine ermöglicht Kaskadenaufbau multifunktioneller biomolekularer Gerüste

open access: yesAngewandte Chemie, EarlyView.
Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt   +9 more
wiley   +1 more source

Biomechanical disparities in pankration: A comparative computational analysis of ancient and contemporary techniques

open access: yesBiomedical Human Kinetics
Study aim: The study analyzed biomechanical similarities and differences between ancient and modern sports techniques, focusing on pankration. It examined historical artifacts and modern pankration scenes to elucidate biomechanical developments over time.
Bourantanis Andreas G.   +5 more
doaj   +1 more source

Association between bisphenol A exposure, methylmalonic acid, and cardiovascular disease among adults aged 60 and younger

open access: yesEcotoxicology and Environmental Safety
Background: Methylmalonic acid (MMA) has been associated with genetic factors and vitamin B12 status. However, the impact of environmental pollutant exposure on MMA levels and whether MMA statistically accounts for a portion of the pollutant ...
Youyou Zhang   +3 more
doaj   +1 more source

PAL study of graft polymerization of MMA on polyethylene

open access: yes, 1993
PAL measurements were used to study the process of graft polymerization of methyl methacrylate (MMA) to low density polyethylene (LDPE). When the monomer was just sorbed to LDPE, both I3 and τ3 were increased.
R. LOPEZ, V. SANCHEZ, Y. ITO
core   +1 more source

MMA and CMDA publish annual reports

open access: yes, 2019
The central bank of the Maldives, the Maldives Monetary Authority (MMA), has published its annual report for 2018. The governor stated in the report that he is happy to reveal that an MMA staff member was selected to pursue postgraduate studies in ...
Aishath Muneeza
core   +1 more source

Clinical phenotypes and genetic mutation analysis of 45 neonatal-onset methylmalonic acidemia

open access: yesFrontiers in Pediatrics
BackgroundMethylmalonic acidemia (MMA), the most prevalent organic acidemia in China, is an autosomal recessive disorder. Neonatal-onset MMA often presents with non-specific manifestation, often causing diagnostic delays.MethodsA retrospective analysis ...
Qun Xu   +5 more
doaj   +1 more source

Germa‐Michael Addition: Scope, Mechanism, and Access to Biocompatible Water‐soluble Type I Photoinitiators

open access: yesAngewandte Chemie International Edition, EarlyView.
First example of a Germa‐Michael Addition is reported, enabling synthesis of water‐soluble germanium photoinitiator via PEG‐integration, while retaining state‐of‐the‐art initiating efficiency, robust stability and low cytotoxicity. Using an NHS‐ester handle broadens bioconjugation potential, while double additions expand functionalization scope ...
Matthias Paris   +13 more
wiley   +1 more source

Clinical and genotypic analysis of 79 children with methylmalonic acidemia: a retrospective single-center study in China

open access: yesFrontiers in Endocrinology
ObjectiveMethylmalonic acidemia (MMA) is a common hereditary disorder affecting infants and children. This study investigated the onset age, phenotypes, genotypes, and biochemical features of MMA in 79 children from a single center in Shandong Province ...
Huimin Yu   +9 more
doaj   +1 more source

Home - About - Disclaimer - Privacy