Results 251 to 260 of about 152,985 (282)

Direct recruitment of TONSOKU by the N-terminal tails of histone variants H2A.X and H2A.W coordinates DNA repair. [PDF]

Sci Adv
Li Q, Zhao C, Guo Y, Bai Y, Liu J, Jin X, Yuan Y, Jacob Y, Dong J.   +8 more
europepmc   +1 more source

On Approximate MMS Allocations on Restricted Graph Classes [PDF]

Václav Blažej, Michał Dębski, Zbigniew Lonc, Marta Piecyk   +3 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Agent-specific DNA repair kinetic in 3T3 cells: a comparative study using the in vitro comet assay. [PDF]

Toxicol Res (Camb)
İpek Tekneci S, Üstündağ A, Duydu Y.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A kinematic-and-muscular modulation strategy for FES-assisted upper limb rehabilitation: a feasibility study. [PDF]

Sci Rep
Demofonti A, Cordella F, Scotto di Luzio F, Iannelli V, Zollo L.   +4 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

CRISPR-Cas targeting in <i>Haloferax volcanii</i> promotes within-species gene exchange by triggering homologous recombination. [PDF]

Microlife
Choudhary DK, Turgeman-Grott I, Robinzon S, Gophna U.   +3 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Research on the characteristics of spatial 6-degree-of-freedom linear inclined vibrating screen. [PDF]

Sci Rep
Huang LX, Liu X, Xiao SG, Song MM, Huang NQ, Miao HT.   +5 more
europepmc   +1 more source