Results 31 to 40 of about 3,489 (154)

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science, EarlyView.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
wiley   +1 more source

Angiotensin II receptor 1 blockage limits brain damage and improves functional outcome after brain injury in aged animals despite age-dependent reduction in AT1 expression [PDF]

, 2019
Traumatic brain injury (TBI) is a frequent pathology associated with poor neurological outcome in the aged population. We recently observed accelerated cerebral inflammation in aged mice in response to TBI.
Gotthardt, Philipp, Huang, Changsheng, Hummel, Regina, Luh, Clara, Schäfer, Michael, Thal, Serge, Timaru-Kast, Ralph   +6 more
core   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Histological and ultrastructural comparison of cauterization and thrombosis stroke models in immune-deficient mice [PDF]

, 2011
Background: Stroke models are essential tools in experimental stroke. Although several models of stroke have been developed in a variety of animals, with the development of transgenic mice there is the need to develop a reliable and reproducible stroke
Abizanda, G. (Gloria), Casado-Nieto, M. (Maite), Garcia-Verdugo, J.M. (José Manuel), Gomez-Pinedo, U. (Ulises), Gutierrez-Perez, M. (María), Jauquicoa, C. (Carlos), Lopez, T. (Tania), Mora-Lee, S. (Silvia), Prosper, F. (Felipe), Romaguera-Ros, M. (Mirian), Sirerol-Piquer, M.S. (María Salomé)   +10 more
core  

A Human Blood Group Antigen, Nya (Nyberg), segregating with the Ns Gene Complex of the MNSs System [PDF]

Nature, 1964
A SAMPLE of human serum was found to contain an antibody to a hitherto unrecognized red blood cell antigen: the corresponding antigen was first found in the cells of Mr. Nyberg and for that reason the antigen is being called Nya, the corresponding gene Nya, and the antibody anti-Nya. Anti-Nya distinguishes two phenotypes, Ny(a+) and Ny(a−).
H, ORJASAETER, L, KORNSTAD, A M, HEIER, E, VOGT, P, HAGEN, O, HARTMANN   +5 more
openaire   +2 more sources

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Distribution of Blood Group Systems in Thai Blood Donors Determined by the Gel Test

Siriraj Medical Journal, 2002
The rapid availability of fully typed donor blood is of great advantage, especially for patients requiring repeated blood transfusions. Only limited blood group antigen typing has been carried out using the conventional tube technique.
Sasitorn Bejrachandra, Oytip Nathalang, Jariya Saipin, Sukunya Kuvanont, Krongthip Wichitchinda, Amporn Vongpattranon   +5 more
doaj  

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms [PDF]

, 2017
Recent evidence suggests that neural stem/precursor cells (NPCs) promote recovery in animal models with delayed neuronal death via a number of indirect bystander effects.
Bacigaluppi, Marco, Brambilla, Elena, Comi, Giancarlo, Hermann, Dirk M., Jametti, Luca Peruzzotti, Kilic, Ertugrul, Kilic, Ülkan, Martino, Gianvito, Pluchino, Stefano, Salani, Giuliana, West, Mark J.   +10 more
core  

Neuroprotective effects of consuming bovine colostrum after focal brain ischemia/reperfusion injury in rat model [PDF]

, 2010
To investigate the neuroprotective effects of bovine colostrums (BC), we evaluate the ability of consuming BC after focal brain ischemia/reperfusion injury rat model to reduce serum cytokine levels and infarct volume, and improve neurological outcome ...
Allan, An, Chan, Chen, Chen, Choi, Chul Cheong, Chun, del Zoppo, Dienz, Dinarello, Dávalos, Feigin, Filipp, Fisher, Goto, Green, Haelewyn, Hagiwara, Hagiwara, Hallenbeck, Han Sung Choi, Hayashida, Iadecola, Jong Seok Lee, Kelly, Ki-Hyo Jang, Kim, Lee, Li, Li, Longa, Lourbopoulos, Oh Young Kwon, Pajkrt, Peroulis, Plaisier, Playford, Playford, Quigley, Saleem, Scumpia, Shing, Shohami, Soon Ah Kang, Sun, Sun-Kyu Kim, Swanson, The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group, Xiao, Young Gwan Ko, Zhang, Zhang   +52 more
core   +2 more sources

Synthetic peptides homologous to human glycophorins of the Miltenberger complex of variants of MNSs blood group system specify the epitopes for Hil, SJL, Hop, and Mur antisera [PDF]

Blood, 1991
The antigenic epitopes of the MNSs blood groups are localized on alpha and delta glycophorins (glycophorins A and B) of the erythrocyte surface. Hil, SJL, Mur, and Hop antisera define the Miltenberger (Mi) complex of MiV, MiJ.L., MiIII, and MiVI variant serologic phenotypes of this blood group system.
K K, Johe, V, Vengelen-Tyler, R, Leger, O O, Blumenfeld   +3 more
openaire   +3 more sources