The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Influence of carbon on the structural-phase composition and hardness of steel ingots of the Fe-Cr-Mo-N-C system obtained by the SHS method under nitrogen pressure [PDF]
Maksim Konovalov +3 more
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AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Effects of pH on the Properties of Mo-Modified Pt/C Synthesized by Microwave-Assisted Method as Catalyst for Electro-Oxidation of Ethanol [PDF]
Zhong Ma +5 more
openalex +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Effects of substrate properties and sputtering methods on self-formation of Ag particles on the Ag–Mo(Zr) alloy films [PDF]
Haoliang Sun +4 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Convenient Quadratic Formulas for the Two-center Coulomb Repulsion Integrals in the Semiempirical LCAO-MO Method and the Significance of the Pariser-Parr Approximation [PDF]
Yasuhiko Gondo, Yoshiya Kanda
openalex +1 more source

