Results 241 to 250 of about 83,177 (340)

Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Qiao Li, Fabian Pfersdorf, Fernando Salgado‐Polo, Martin Gustavsson   +3 more
wiley   +1 more source

QSAR modelling of pesticide modes of toxic action across trophic levels via multi-label extreme gradient boosting. [PDF]

Pest Manag Sci
Mei S.
europepmc   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1-mediated macrophage polarization via the PI3K/Akt pathway. [PDF]

Animal Model Exp Med
Yang F, Li T, Jia W, Xu D, Sun L, Ge Y, Shi Y, Xu H, Song X, Jin F, Mao N.   +10 more
europepmc   +1 more source

High-precision dating and ancient DNA profiling of moa (Aves: Dinornithiformes) eggshell documents a complex feature at Wairau Bar and refines the chronology of New Zealand settlement by Polynesians

, 2014
C. Jacomb, R. Holdaway, Morten E. Allentoft, M. Bunce, C. Oskam, R. Walter, E. Brooks   +6 more
semanticscholar   +1 more source

Run to the Caves: Frog Refuges From Harsh Environments

Biotropica, Volume 58, Issue 6, November 2026.
ABSTRACT The use of caves by primarily nontroglobiont organisms can be critical when the conditions of surrounding epigean habitats deteriorate as a result of synergic effects of climate changes and degradation of native vegetation cover. Under scenarios of unbalanced temperatures, high solar incidence, low humidity and reduced shelter availability in ...
Rafael de Fraga, Cassia de Carvalho Teixeira, Valéria da Cunha Tavares, Xavier Prous, Gilmax Ferreira, Carlos Eduardo de Araújo Batista, Leonardo Carreira Trevelin   +6 more
wiley   +1 more source

Advancing next-generation risk assessment for cosmetic ingredients: transferring the 10-step read-across framework from human to environmental safety using triclosan as a case study. [PDF]

NAM J
Streicher H, Mishra S, Naddi Z, Fernandes R, Autiero M, Krause S, Suri AK, De Roy C, Schepky A, Najjar A.   +9 more
europepmc   +1 more source

Amino Acids in the RSSY Motif of Lipoyl Synthase Control Substrate Binding and Reactivity. [PDF]

ACS Bio Med Chem Au
Jeyachandran VR, Lanz ND, Pandelia ME, Rectenwald JM, Pendyala JV, Maurya RK, Boal AK, Krebs C, Booker SJ.   +8 more
europepmc   +1 more source

Oleanolic Acid‐Enriched Olive Oil Attenuates Kidney Function Decline in Patients With Type 2 Diabetes: Results From the OLTRAD Randomised Controlled Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10195-10209, November 2026.
ABSTRACT Aims Chronic kidney disease (CKD) is a major complication of type 2 diabetes mellitus (T2DM), driven in part by oxidative stress and the accumulation of advanced glycation end products (AGEs). Oleanolic acid (OA), a natural triterpene present in olive‐derived matrices, may modulate AGE metabolism.
Aída García‐González, Alejandro Matamoros‐Domínguez, Juan Manuel Espinosa‐Cabello, Gisela Pérez‐Muñoz, Manuel Jesús León Aranda, María Del Carmen Roque‐Cuellar, Silvia García‐Rey, Andrés Jiménez‐Sánchez, Antonio Jesús Martínez‐Ortega, Miguel Ángel Mangas‐Cruz, Isabel Cerrillo, Javier S. Perona, Pedro Pablo García‐Luna, Elena María Yubero‐Serrano, José María Castellano   +14 more
wiley   +1 more source