Results 191 to 200 of about 376,338 (268)

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Development of a standard operating procedure for investigational product rights of administration in clinical trials. [PDF]

J Clin Transl Sci
Hill L, Jones CT.
europepmc   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

KETAMIR-2, a new molecular entity and novel ketamine analog. [PDF]

Front Pharmacol
Angel I, Perelroizen R, Deffains W, Adraoui FW, Pichinuk E, Aminov E.   +5 more
europepmc   +1 more source

Nanosized Li2S‐Loaded Polar Porous Carbon Nanofibers as Self‐Supporting Electrodes in Anode‐Free Lithium–Sulfur Batteries

Advanced Science, EarlyView.
Anode‐free Li–S cells are realized by coupling nano‐Li2S embedded in P‐doped porous carbon nanofibers (Li2S@P‐CNFs) with lithium‐free P‐CNF current collectors. Polar P‐CNFs accelerate Li2S conversion and suppress shuttling, while their lithiophilic, macroporous network homogenizes Li plating for dendrite‐free deposits.
Ping Feng, Qingping Wu, Yaolin Xu, Liqiang Lu, Tianle Zheng, Tonghui Xu, Wen Xu, Daniel Höche, Zdravko Kochovski, Yan Lu   +9 more
wiley   +1 more source

Long-term atorvastatin improves cognitive function by modulating SIRT2-mediated dynamic transition of NFL lysine 272 crotonylation to ubiquitination in naturally aging rats. [PDF]

Cell Death Discov
Xu TC, Cai JR, Chen HS.
europepmc   +1 more source

Mussel‐Bioinspired Edible Ca2+‐Crosslinked Alginate Hydrogel Electrodes for Glucose Gastrointestinal Monitoring

Advanced Science, EarlyView.
A fully edible soft electrode is engineered from Ca2⁺‐crosslinked alginate integrated with polydopamine, silver nanoparticles, and food‐grade glucose oxidase. The hybrid hydrogel combines ionic and electronic conduction, enabling efficient glucose‐to‐H2O2 conversion and catalytic reduction in simulated intestinal fluid.
Verdiana Marchianò, Claudio Pellegrini, Angelo Tricase, Eleonora Macchia, Andrea Brattelli, Luigi Gentile, Patrizia Nadia Hanieh, Noemi Fiaschini, Antonio Rinaldi, Luisa Torsi, Paolo Bollella   +10 more
wiley   +1 more source

Social Vulnerability Predictors of Acute Care: Leveraging Health Information Exchange Data to Understand Social Determinants at the Census Tract Level in a Correlational Study. [PDF]

Health Sci Rep
Pellegrin KL, Barbour TB, Lozano AJ, Hanlon AL.   +3 more
europepmc   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Influences of formulations and administration routes on docetaxel tissue distribution in mice. [PDF]

Sci Rep
Dong X, Zhang T, Shah B, Bae SH, Mans JC.   +4 more
europepmc   +1 more source