Results 201 to 210 of about 376,338 (268)

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

A Star-PEGylation Strategy to Improve Testosterone Pharmacokinetics. [PDF]

Molecules
Lee CB, Tenora L, Zhang R, Ranjit A, Markowski MC, Slusher BS, Rais R.   +6 more
europepmc   +1 more source

Scalable Photoactive NO2‐Sensing Framework for Plant Health Monitoring

Advanced Science, EarlyView.
A highly sensitive and selective NO2 gas sensor operates at room temperature using only ambient light, eliminating the need for external heating. Based on a scalable, 3D TiO2 nanoarchitecture, the device is integrated into a wireless platform and deployed on a plant. It successfully demonstrates real‐time monitoring of gas‐induced physiological stress,
Yun‐Haeng Cho, Kootak Hong, Jung Hwan Seo, Jae Han Chung, Jinho Lee, Sang‐Hyeon Nam, Sunwoo Lee, Jeong‐O Lee, Changui Ahn, Hyojung Kim, Jae Hyun Han, Gyu‐Li Kim, Seong‐Jun Ro, Jun Yeon Hwang, Hyeongyu Gim, Zion Park, Chil‐Hyoung Lee, Dong‐Su Kim, Kwangjae Lee, Young‐Seok Shim, Jun Min Suh, Donghwi Cho   +21 more
wiley   +1 more source

Antibiotics accumulate in <i>Klebsiella pneumoniae</i> liver abscesses but fail to eliminate antibiotic-tolerant populations. [PDF]

Proc Natl Acad Sci U S A
Angeles-Solano M, Tabashsum Z, Liu JD, Lifschin ZJ, Wagner NJ, Tyson KJ, Chen L, Sellers RS, Walker KA, Desyaterik Y, Rosen EP, Rowe SE.   +11 more
europepmc   +1 more source

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

Advanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang, Xiaohui Tao, Ning Zhang, Xin Yang, Hewen Jiang, Xiaofei Li, Shenghang Wang, Shijian Ding, Sifan Yu, Huarui Zhang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Xianghang Luo, Tao Zhang, Shu Zhang, Péter Ferdinandy, Yu Huang, Daqing Ma, Aiping Lu, Baoting Zhang, Ge Zhang   +27 more
wiley   +1 more source

Biomarker studies to predict outcomes of patients with COVID-19 related acute respiratory distress syndrome measured pre and post initiation of veno venous extracorporeal membrane oxygenation. [PDF]

Sci Rep
Odish MF, Gage H, Lam MTY, Hepokoski M, Pollema T, Tong K, Liu L, Malhotra A, Owens RL, Meier A.   +9 more
europepmc   +1 more source

Interlayer Dzyaloshinskii–Moriya Interaction in Synthetic Ferrimagnets for Spiking Neural Networks

Advanced Science, EarlyView.
This work introduces a groundbreaking integration of asymmetric magnetic structures (synthetic ferrimagnets) and antisymmetric magnetic interaction (interlayer Dzyaloshinskii–Moriya interaction) for the first time. It addresses the critical challenge of IL‐DMI detection and shows the discovery of unprecedented analog‐like spin‐orbit torque switching ...
Shen Li, Xing Chen, Mouad Fattouhi, Tianxun Huang, Chen Lv, Mark C. H. de Jong, Pingzhi Li, Daoqian Zhu, Xiaoyang Lin, Felipe Garcia‐Sanchez, Eduardo Martinez, Stéphane Mangin, Bert Koopmans, Weisheng Zhao, Reinoud Lavrijsen   +14 more
wiley   +1 more source

Development of Enhanced Separation Techniques for Oligonucleotides Utilizing Mixed-Mode Chromatography and 2D-LC/UV/MS Analysis. [PDF]

J Sep Sci
Haglöf J, Nilsson JM, Ludvigsson JW.
europepmc   +1 more source

Gut Microbe‐Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Advanced Science, EarlyView.
Acinetobacter regulates dinotefuran tolerance in Propylea japonica by mediating the expression of the horizontally transferred gene PjDUF1. Abstract Insect–microbial symbiont relationships are widespread in nature and often involve lateral gene transfer.
Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao   +10 more
wiley   +1 more source

Dilution Effect for High‐Performance Multiple‐Component Near‐Infrared Organic Photodetectors

Advanced Science, EarlyView.
The dilution effect in multi‐component organic photodetector effectively suppresses non‐radiative decay and minimizes dark current, while energy‐level‐offset‐governed electron transfer between acceptors maintains efficient charge transport. This synergistic mechanism collectively enables remarkable device performance, including high detectivity and ...
Zhuang Li, Xunchang Wang, Xiaosong Qiu, Xinpeng Yang, Linming Bi, Jin Chen, Qian Wang, Yurong He, Jingyi Xiong, Renqiang Yang   +9 more
wiley   +1 more source