Results 31 to 40 of about 1,360,693 (295)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

When outcome expectations become habitual: explaining vs. predicting new media technology use from a social cognitive perspective [PDF]

open access: yes, 2007
This study examined the triadic relationship between expected outcomes, habit strength, and media technology use within the model of media attendance (Larose & Eastin, 2004).
Peters, Oscar
core   +1 more source

Implementing a Mobile Social Media Framework for Designing Creative Pedagogies [PDF]

open access: yes, 2014
The rise of mobile social media provides unique opportunities for new and creative pedagogies. Pedagogical change requires a catalyst, and we argue that mobile social media can be utilized as such a catalyst.
Balsamo   +22 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Generation M2: Media in the Lives of 8- to 18-Year-Olds [PDF]

open access: yes, 2010
Examines trends in which media youth use, for how much time, how new media platforms have affected media consumption, what role mobile and online media play, what media environment youth live in, and how patterns vary by gender, age, and race ...
Donald F. Roberts   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Understanding the Participatory News Consumer [PDF]

open access: yes, 2010
Analyzes survey findings on the impact of social media and mobile connectivity on news consumption behavior by demographics and political affiliation.
Amy Mitchell   +4 more
core  

Information spreading during emergencies and anomalous events

open access: yes, 2017
The most critical time for information to spread is in the aftermath of a serious emergency, crisis, or disaster. Individuals affected by such situations can now turn to an array of communication channels, from mobile phone calls and text messages to ...
Bagrow, James P.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

The impact of mobile journalism on public opinion [PDF]

open access: yesمطالعات رسانه‌های نوین, 2019
:The mobile journalism and its impact on production and news publication has led to more public opinion. Pattern of publication (Publish then filter),(Down to Up),(One to all), The most important distinction is this new type of journalism.Although ...
Mahdi Adiban, aliasghar kiya
doaj   +1 more source

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