Results 221 to 230 of about 12,549,335 (257)

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

The implementation of a smart safety protection system using DL and IoT technologies. [PDF]

PLoS One
Omri K, Himdi H, Khayyat MM, Eshmawi AA, Khayyat MM.   +4 more
europepmc   +1 more source

The Effects of Armed Conflict on Healthcare Delivery and Nutritional Services in Somalia: A Narrative Review. [PDF]

Public Health Chall
Elmi AH.
europepmc   +1 more source

Fuzzy Identity-Based Signature Scheme Suitable for Biometric Authentication. [PDF]

Sensors (Basel)
Qu Y, Ke C, Tian S, Yang M, Wang N.
europepmc   +1 more source

Primary Grocery Shopping Location is Associated With Vegetable Consumption in Underserved Communities. [PDF]

J Nutr Educ Behav
Leone LA, Lally Mathiebe A, Kasprzak C, Haynes-Maslow L, Raja S, Vermont LN, Tumiel-Berhalter L, Paluch R, Ammerman A.   +8 more
europepmc   +1 more source