The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
The news media are among the most important sources of information about political events, such as referendums. For young adults, the smartphone has become the main device for accessing news.
Daniel Vogler +7 more
doaj +1 more source
Mobile air quality studies (MAQS) in inner cities: particulate matter PM10 levels related to different vehicle driving modes and integration of data into a geographical information program [PDF]
: BACKGROUND: Particulate matter (PM) is assumed to exert a major burden on public health. Most studies that address levels of PM use stationary measure systems.
Fischer, Axel +10 more
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A la actual Política Nacional de Producción más Limpia y Consumo Sostenible en Colombia se han articulado programas en diversos sectores productivos, uno de estos enfocado al sector transporte de carga, desde el 2008.
Miryam Gómez Marín. +3 more
doaj
Emission inventory of criteria pollutants Costa Rica in 2011
Criteria pollutant emissions were determined in Costa Rica in 2011, from the application of emission factors, measurement sources, the application of mechanistic models and material balance.
Jorge Herrera
doaj +1 more source
Contributions of mobile, stationary and biogenic sources to air pollution in the Amazon rainforest: a numerical study with the WRF-Chem model [PDF]
This paper evaluates the contributions of the emissions from mobile, stationary and biogenic sources on air pollution in the Amazon rainforest by using the Weather Research and Forecasting with Chemistry (WRF-Chem) model.
S. A. Abou Rafee +12 more
doaj +1 more source
Internet source evaluation: The role of implicit associations and psychophysiological self-regulation [PDF]
This study focused on middle school students\u2019 source evaluation skills as a key component of digital literacy. Specifically, it examined the role of two unexplored individual factors that may affect the evaluation of sources providing information ...
Mason, L +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Application of Biological Learning Theories to Mobile Robot Avoidance and Approach Behaviors [PDF]
We present a neural network that learns to control approach and avoidance behaviors in a mobile robot using the mechanisms of classical and operant conditioning.
Chang, Caroilna, Gaudiano, Paolo
core +3 more sources

