Results 121 to 130 of about 422,750 (312)
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Urban Mobility: Mobile Crowdsensing Applications
, 2018 Mobility has become one of the most difficult challenges that cities must face. More than half of world’s population resides in urban areas and with the continuously growing population it is imperative that cities use their resources more efficiently.
João Simões +3 more
openaire +2 more sources
Advanced Science, EarlyView.In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin +8 more
wiley +1 more source
Stratification, its Problems, in Yield Surveys in Egypt [PDF]
The Egyptian Statistical Journal, 1962 Reda Kandil
doaj +1 more source
Economics Letters, 2020 This short note constructs Mobility Zones to facilitate the discussion on the geographic extent of individual mobility restrictions to control the spread of Covid-19. Mobility Zones are disjoint sets of counties where a given level of individual mobility directly or indirectly connects all counties within each set.
openaire +3 more sources
Advanced Science, EarlyView.A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki +5 more
wiley +1 more source
Oxfam in Action: Community mobilization for ending violence against women [PDF]
, 2015 Violence against women (VAW) is one of the most widespread and least-recognized human rights violations across the world. Of its many manifestations, domestic violence is one of the most pervasive forms.
Misra, Savvy Soumya
core +1 more source
Size and Characteristics of Primary Migrants in Egypt before and After the Migration Process [PDF]
المجلة المصرية للسکـان وتنظيم الأسرة, 1984 Fawzi Gomah Torki
doaj +1 more source
Advanced Science, EarlyView.A microfluidic device with monolithically integrated nanostructures enables high‐throughput wounding of the cell membrane and nuclear envelope. The spatial distribution of charged multivesicular body protein 4B (CHMP4B) within the cell is mapped before and after wounding, showing involvement in repair of both the cell membrane and nuclear envelope ...
Apresio K. Fajrial +5 more
wiley +1 more source
Rural financial savings mobilization in Sri Lanka: Bottlenecks and reform proposals [PDF]
The objective of the following study is to evaluate rural deposit mobilization programmes in Sri Lanka, to identify major bottlenecks in the national savings system, and to provide recommendations for improving rural (financial) savings mobilization for ...
Fischer, Bernhard
core