Results 81 to 90 of about 41,206 (268)

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Permafrost and lakes control river isotope composition across a boreal Arctic transect in the Western Siberian lowlands

Environmental Research Letters, 2018
The Western Siberian Lowlands (WSL) store large quantities of organic carbon that will be exposed and mobilized by the thawing of permafrost. The fate of mobilized carbon, however, is not well understood, partly because of inadequate knowledge of ...
P Ala-aho, C Soulsby, O S Pokrovsky, S N Kirpotin, J Karlsson, S Serikova, R Manasypov, A Lim, I Krickov, L G Kolesnichenko, H Laudon, D Tetzlaff   +11 more
doaj   +1 more source

Des îlots de littérature. Formes et représentations de la langue littéraire dans des textes de cycle 3 et de CLIS

Repères, 2009
The article attempts to analyse pupils’ representations of literary language through the comparative study of texts written in literary and non literary contexts in two cycle 3 primary school classes and a CLIS special needs class.
Thierry Berthou, Daniel Calvarin, Claire Doquet-Lacoste, Élisabeth Le Bouffo   +3 more
doaj   +1 more source

Flexoelectricity in Photoconversion: Fundamentals, Materials, and Outlooks

Advanced Science, EarlyView.
Mechanical bending of a flexible cantilever induces a strain gradient in the photoactive material. The resulting flexoelectric field couples with photovoltaic and photoconductive effects, modulating charge generation, separation, and collection. A comparative analysis of oxide perovskites, halide perovskites, and two‐dimensional materials is presented,
Xiang Huang, Feng Li, Rongkun Zheng
wiley   +1 more source

Site effect studies following the 2016 Mw 6.0 Amatrice earthquake (Italy): the Emersito Task Force activities

Annals of Geophysics, 2016
On August 24, 2016, at 01:36 UTC a MW 6.0 earthquake struck an extensive area of the central Apennines (Italy). It was followed by a large aftershock (MW 5.3, August 24, 02:33 UTC) and about 20 earthquakes with magnitude greater than 4.0, located between
Giovanna Cultrera, Ezio D'Alema, Sara Amoroso, Barbara Angioni, Paola Bordoni, Luciana Cantore, Fabrizio Cara, Arrigo Caserta, Rocco Cogliano, Maria D'Amico, Giuseppe Di Giulio, Deborah Di Naccio, Daniela Famiani, Chiara Felicetta, Antonio Fodarella, Sara Lovati, Lucia Luzi, Marco Massa, Alessia Mercuri, Giuliano Milana, Francesca Pacor, Marta Pischiutta, Stefania Pucillo, Rodolfo Puglia, Gaetano Riccio, Gabriele Tarabusi, Maurizio Vassallo, Claudia Mascandola   +27 more
doaj   +1 more source

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

Advanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li, Li Peng, Laiya Lu, Yingying Wang, Xiaolei Chen, Feng Yin, Cuijun Deng, Yu Cheng   +7 more
wiley   +1 more source

A violência sob o olhar de lideranças comunitárias de Londrina, Paraná, Brasil Violence from the perspective of community leaderships in Londrina, Paraná, Brazil

Saúde e Sociedade, 2010
Estudos têm mostrado que a mobilização popular é importante para se combater a violência. Este trabalho identificou a visão que lideranças comunitárias de duas regiões da periferia da cidade de Londrina-PR, com diferentes níveis de mobilização popular ...
Marcia Caroline Portela Amaro, Selma Maffei de Andrade, Mara Lúcia Garanhani   +2 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Trajetórias, atributos e relações. Representações sobre redes e obtenção de trabalho

REDES: Revista Hispana para el Análisis de Redes Sociales, 2012
The article aims at contributing to recent analysis on how people get access to job opportunities and the role of different mechanisms mobilized on it, with special interest in personal contacts.
Nadya Araujo Guimarães, Ana Carolina Silva Andrada, Monise Fernandes Picanço, Priscila Pereira, Faria Vieira   +4 more
doaj