Beyond Moco Biosynthesis―Moonlighting Roles of MoaE and MOCS2 [PDF]
Molecules, 2022 Molybdenum cofactor (Moco) biosynthesis requires iron, copper, and ATP. The Moco-containing enzyme sulfite oxidase catalyzes terminal oxidation in oxidative cysteine catabolism, and another Moco-containing enzyme, xanthine dehydrogenase, functions in ...
Tamaki Suganuma
exaly +4 more sources
Two mild phenotype molybdenum cofactor deficiency patients with novel MOCS2 mutation and immunological treatment after COVID-19 infection. [PDF]
BMC NeurologyBackground Molybdenum cofactor deficiency type B (MoCD-B) is a rare autosomal recessive metabolic disorder caused by mutations in MOCS2. Patients with mild phenotypes may experience infection-related neurological deterioration followed by partial ...
Kelu Zheng, Yani Zhang, Zhen Shi
exaly +3 more sources
Metabolic reprogramming signature predicts prognosis and immune landscape in small cell lung cancer: MOCS2 validation and implications for personalized therapy [PDF]
Frontiers in Molecular BiosciencesIntroductionSmall cell lung cancer (SCLC) remains a leading cause of cancer mortality worldwide, characterized by rapid progression and poor clinical outcomes, and the function of metabolic reprogramming remains unclear in SCLC.MethodsWe performed multi ...
Shenghu Guo
exaly +4 more sources
A case report of MoCD etiology in a neonate: A novel homozygous MoCS2 variant [PDF]
Clinical Case Reports (discontinued)Key Clinical Message Molybdenum cofactor deficiency is a rare and fatal genetic disorder. Due to recurrence in the family, the etiological diagnosis could have impacted family planning and alertness to future offspring.
Jamal Sayed, Ahmed Gamal Sayed
exaly +3 more sources
Molybdenum Cofactor Deficiency in Humans [PDF]
Molecules, 2022 Molybdenum cofactor (Moco) deficiency (MoCD) is characterized by neonatal-onset myoclonic epileptic encephalopathy and dystonia with cerebral MRI changes similar to hypoxic–ischemic lesions.
Guenter Schwarz, Chun-Yu Fu
exaly +4 more sources
Identification and verification of prognostic cancer subtype based on multi-omics analysis for kidney renal papillary cell carcinoma [PDF]
Frontiers in Oncology, 2023 BackgroundIdentifying Kidney Renal Papillary Cell Carcinoma (KIRP) patients with high-risk, guiding individualized diagnosis and treatment of patients, and identifying effective prognostic targets are urgent problems to be solved in current research on ...
Baodong Wang, Mei Li, Rongshan Li
doaj +2 more sources
Ocular characteristics of a 6-year-Old boy with molybdenum cofactor deficiency type B [PDF]
American Journal of Ophthalmology Case Reports, 2022 Purpose: To report a rare case of Molybdenum Cofactor Deficiency with novel ocular manifestations. Observations: This is a case study of a 6-year-old boy who initially presented with conjunctival hyperemia and ocular pain of the left eye. Medical history
Wenjia Yan +3 more
doaj +2 more sources
A New Pattern of Brain and Cord Gadolinium Enhancement in Molybdenum Cofactor Deficiency: A Case Report [PDF]
Children, 2023 Molybdenum cofactor deficiency (MoCD) is a rare and severe autosomal recessive in-born error of metabolism caused by the mutation in MOCS1, MOCS2, MOCS3 or GEPH genes, with an incidence ranging between 1 in 100,000 and 200,000 live births.
Giulia Lucignani +11 more
doaj +2 more sources
Novel pathogenic variant in a mild case of type B molybdenum cofactor deficiency: case report and literature review [PDF]
BMC Medical GenomicsBackground Molybdenum cofactor deficiency (MoCD) is a rare metabolic disorder caused by pathogenic variants in the highly conserved biosynthetic pathway of molybdenum cofactor (MoCo), resulting in sulfite intoxication.
Morgan Kinsinger +2 more
doaj +2 more sources
Examining the liver–pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration [PDF]
Life Science AllianceInvestigation of the inter-organ, pancreas–liver, crosstalk reveals a potential role of the molybdenum biosynthetic pathway in β-cell regeneration. Regeneration of insulin-producing β-cells is an alternative avenue to manage diabetes, and it is crucial ...
Christos Karampelias +10 more
doaj +2 more sources