Results 191 to 200 of about 1,564,204 (345)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Global mapping of disaggregated international trade-linked transportation CO₂ emissions. [PDF]

Sci Adv
Luo Z, Soo Y, Lv Z, Cong W, Wang X, Qu S, He T, Yi W, Deng C, Xie Y, Liu H, He K.   +11 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

DEF-Net: A dual-modal feature enhancement and fusion network for infrared and visible object detection. [PDF]

PLoS One
Guo X, Yang F, Ji L.
europepmc   +1 more source

Reviewer #3 (Public review): Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

openalex   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

ASYM: multimodal depression recognition via mamba-enhanced attentive feature fusion. [PDF]

Front Psychiatry
Hua C, Wen Z, Li L, Zhou X.
europepmc   +1 more source

Facing "The Book" : investigating the discursive construction of Facebook through multiple modalities and the consequent construction of ideology.

, 2010
Daniela Nortje
openalex   +1 more source

AM$^3$Safety: Towards Data Efficient Alignment of Multi-modal Multi-turn Safety for MLLMs

Han Zhu, Jiale Chen, Chengkun Cai, Shengjie Sun, Haoran Li, Yujin Zhou, Chi-Min Chan, Pengcheng Wen, Lei Li, Sirui Han, Yike Guo   +10 more
openalex   +1 more source

DEONTIC MODALITY AND MODALS IN THE LANGUAGE OF CONTRACTS

Comparative Legilinguistics, 2016
The purpose of this paper is to present most typical methods of expressing deontic modality, namely obligation, prohibition and permission in Polish, American and British contracts. The author has analyzed the corpora of about 45 contracts formulated in British-English, American-English and Polish, namely: (i) deeds of conveyance, (ii) contracts of ...
openaire   +2 more sources