Results 281 to 290 of about 2,324,474 (375)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Soft‐Layered Composites with Wrinkling‐Activated Multi‐Linear Elastic Behavior, Stress Mitigation, and Enhanced Strain Energy Storage

open access: yesAdvanced Engineering Materials, EarlyView.
In this study, exciting new bi‐/multi‐linear elastic behavior of soft elastic composites that accompany the activation of wrinkling in the embedded interfacial layers is analyzed. The new features and performance of these composite materials, including dramatic enhancements in energy storage, can be tailored by the concentration of interfacial layers ...
Narges Kaynia   +2 more
wiley   +1 more source

Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics

open access: yesAdvanced Engineering Materials, EarlyView.
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani   +2 more
wiley   +1 more source

Development and Validation of a One‐Dimensional Finite Difference Simulation Scheme for Polymer Laser Powder Bed Fusion with Application to the Effect of the Inter Layer Time

open access: yesAdvanced Engineering Materials, Volume 27, Issue 14, July 2025.
The study presents an efficient simulation approach for the polymer laser powder bed fusion process polymers process, validated with polyamide 12, polyamide 6, and polyetherketoneketone. It shows that inter layer time affects part density, with 90s yielding dense parts.
Claas Bierwisch   +4 more
wiley   +1 more source

A multiplex of connectome trajectories enables several connectivity patterns in parallel. [PDF]

open access: yesElife
Mostame P   +9 more
europepmc   +1 more source

Development of Ternary Magnesium Alloys for Laser Powder Bed Fusion: Optimizing Oxide Layer Thickness

open access: yesAdvanced Engineering Materials, Volume 27, Issue 14, July 2025.
Additive manufacturing of magnesium alloys by laser is difficult because the melting point of the oxide layer is much higher than the evaporation temperature of the metal underneath. Making the oxide layer thinner can solve this problem. Alloying magnesium with strontium makes the oxide layer thinner, especially at 0.5 wt%.
Elmar Jonas Breitbach   +8 more
wiley   +1 more source

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