Results 41 to 50 of about 1,072,805 (301)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Inadequacy of Modal Logic in Quantum Settings [PDF]
Electronic Proceedings in Theoretical Computer Science, 2019 We test the principles of classical modal logic in fully quantum settings. Modal logic models our reasoning in multi-agent problems, and allows us to solve puzzles like the muddy children paradox.
Nuriya Nurgalieva, Lídia del Rio
doaj +1 more source
Phonetic Possibility and Modal Logic [PDF]
, 2007 In this paper I propose a formalization, using modal logic, of the notion of possibility that phoneticians use when they judge speech sounds to be possible or impossible.
Sharlow, Mark
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
, 2000 KLAIM is an experimental programming language that supports a programming paradigm where both processes and data can be moved across different computing environments. The language relies on the use of explicit localities, and on allocation environments that associate logical localities to physical sites.
DE NICOLA, ROCCO, LORETI, MICHELE
openaire +4 more sources
Lindstrom theorems for fragments of first-order logic [PDF]
Logical Methods in Computer Science, 2009 Lindstr\"om theorems characterize logics in terms of model-theoretic conditions such as Compactness and the L\"owenheim-Skolem property. Most existing characterizations of this kind concern extensions of first-order logic.
Johan van Benthem +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
A simple modal logic for belief revision [PDF]
We propose a modal logic based on three operators, representing intial beliefs, information and revised beliefs. Three simple axioms are used to provide a sound and complete axiomatization of the qualitative part of Bayes’ rule.
Giacomo Bonanno
core +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source