Results 101 to 110 of about 252,394 (298)

Tension mediated nonlinear coupling between orthogonal mechanical modes of nanowire resonators

open access: yes, 2018
We study the nonlinear coupling between orthogonal flexural modes of doubly clamped InAs nanowire resonators. The two orthogonal modes are formed by the symmetry breaking and lifting of degeneracy of the fundamental mode.
Bhushan, Anand   +2 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

ASSESASSESSING PERCEPTIONS TOWARDS PUBLIC BUS SERVICE AMONG THE CAR USERS IN ISKANDAR MALAYSIASING PERCEPTIONS TOWARDS PUBLIC BUS SERVICE AMONG THE CAR USERS IN ISKANDAR MALAYSIA

open access: yesInternational Journal of Built Environment and Sustainability, 2019
Encouraging car users to bus use has been a central topic to control the deteriorating traffic condition. In this light, Iskandar Regional Development Authority (IRDA) has deployed extensive investments in order to improve public bus service on its ...
Jia Chyi Pung, Safizahanin Mokhtar
doaj   +1 more source

Impact of COVID-19: A radical modal shift from public to private transport mode. [PDF]

open access: yesTransp Policy (Oxf), 2021
Das S   +5 more
europepmc   +1 more source

Investigations of Bragg reflectors in nanowire lasers

open access: yes, 2012
The reflectivity of various Bragg reflectors in connection to waveguide structures, including nanowires, has been investigated using modal reflection and transmission matrices.
Skaar, Johannes   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Piling up or Packaging Policies? An Ex-Post Analysis of Modal Shift in Four Cities

open access: yesEnergies, 2018
Recently, there has been wider acknowledgement that sustainable urban mobility will not be triggered by one ‘silver bullet’ policy, or by piling up various policies, but requires a deliberate package of policies.
Marc Dijk, Moshe Givoni, Karen Diederiks
doaj   +1 more source

Fluid mass and thermal loading effects on the modal characteristics of space shuttle main engine liquid oxygen inlet splitter vanes [PDF]

open access: yes
An analysis and evaluation of experimental modal survey test data on the variations of modal characteristics induced by pressure and thermal loading events are presented. Extensive modal survey tests were carried out on a Space Shuttle Main Engine (SSME)
Boehnlein, J. J., Panossian, H. V.
core   +1 more source

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