Results 81 to 90 of about 252,394 (298)

Promoting walking and cycling as an alternative to using cars: systematic review [PDF]

, 2004
Objectives: To assess what interventions are effective in promoting a population shift from using cars towards walking and cycling, and to assess the health and distributional effects of such interventions.
Egan, M., Hamilton, V., Ogilvie, D., Petticrew, M.   +3 more
core   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Beyond expected travel time: Unveiling the role of ergodicity breaking in mobility decisions and effective transportation policy

Transportation Research Interdisciplinary Perspectives
In this paper, we direct the attention of the mobility science community to the concept of ergodicity-breaking, a principle of importance for understanding and addressing the complexities of (personal) mobility. Ergodicity refers to the assumption that a
Arne Vanhoyweghen, Vincent Ginis, Cathy Macharis   +2 more
doaj   +1 more source

Modal Competition and Complementarity: Cost Optimization at End-User Level

Romanian Journal of Transport Infrastructure, 2018
The paper aims to identify possible methods for balancing the allocation of transport flow on modal subsystems in order to efficiently use the infrastructures and reduce the negative effects of today’s unbalance. The aspects of intermodal competition are
Costescu Dan M.
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Le coût économique du report modal vers le tramway: Aspects conceptuels et méthodologiques de la prise en compte des effets du report modal dans l'évaluation économique des projets de transports collectifs [PDF]

, 2009
The modal shift of car users towards public transport is a key objective of most investment projects in tramways networks. The cost-benefit analysis of these projects poses many conceptual and practical problems, and work is underway in various ...
Darbéra, Richard
core   +2 more sources

Gestalt Shifts in the Liar Or Why KT4M Is the Logic of Semantic Modalities [PDF]

, 2017
: This chapter offers a revenge-free solution to the liar paradox (at the centre of which is the notion of Gestalt shift) and presents a formal representation of truth in, or for, a natural language like English, which proposes to show both why -- and ...
Bobzien, Susanne
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Grafting Hypersequents onto Nested Sequents

, 2015
We introduce a new Gentzen-style framework of grafted hypersequents that combines the formalism of nested sequents with that of hypersequents. To illustrate the potential of the framework, we present novel calculi for the modal logics $\mathsf{K5}$ and $\
Kuznets, Roman, Lellmann, Björn
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source