Results 51 to 60 of about 1,487,216 (331)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Hyflex Teaching and Learning: an Alternative Modality for Meaningful Engagement and Epistemological Access in South African Higher Education

open access: yesE-Journal of Humanities, Arts and Social Sciences, 2022
Hyflex teaching and learning is relatively a new concept within the South African higher education context. This teaching and learning approach brings to the fore the possibility of combining the existing teaching platforms for maximizing not only ...
Thamsanqa Abednigo Ndlovu   +1 more
doaj   +1 more source

Deciding definability in FO2( [PDF]

open access: yes, 2015
We provide a decidable characterization of regular forest languages definable in FO2(
Place, Thomas, Segoufin, Luc
core   +5 more sources

Modal indefinites [PDF]

open access: yesNatural Language Semantics, 2009
Across languages, we find indefinites that trigger modal inferences. This article contributes to a semantic typology of these items by contrasting Spanish algun with indefinites like German irgendein or Italian uno qualsiasi. While irgendein-type indefinites trigger a Free Choice effect (Kratzer and Shimoyama 2002; Chierchia 2006), algun simply signals
Alonso-Ovalle, Luis   +1 more
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

The integrative model of resiliency in higher education seekers in war conditions

open access: yesMedičnì Perspektivi, 2023
The article presents the results of the study of “The Integrative Model of Resiliency” in higher education seekers in war conditions. 174 higher education seekers were examined, among them: 144 students of the 4th-6th year of the medical faculty and the ...
V.V. Ogorenko   +3 more
doaj   +1 more source

Cavitation and ventilation modalities during ditching

open access: yes, 2019
The flow taking place in the rear part of the fuselage during the emergency landing on water is investigated experimentally in realistic conditions. To this aim, tests on a double curvature specimen have been performed at horizontal velocities ranging ...
Grizzi, Silvano, Iafrati, Alessandro
core   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Resource modalities in game semantics [PDF]

open access: yes, 2007
The description of resources in game semantics has never achieved the simplicity and precision of linear logic, because of a misleading conception: the belief that linear logic is more primitive than game semantics. We advocate instead the contrary: that
Melliès, Paul-André, Tabareau, Nicolas
core   +2 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

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