Results 61 to 70 of about 1,618,868 (330)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The semiotics of A. J. Greimas: A European intellectual heritage seen from the inside and the outside

Sign Systems Studies, 2017
The essay deals with the formation of the Greimassian thought from its earliest origins in his young years at Kaunas University, i.e. his connections with Wilhelm Sesemann, Lev Karsavin and Russian formalism, to the rise of structuralism in Paris.
Eero Tarasti
doaj   +1 more source

The integrative model of resiliency in higher education seekers in war conditions

Medičnì Perspektivi, 2023
The article presents the results of the study of “The Integrative Model of Resiliency” in higher education seekers in war conditions. 174 higher education seekers were examined, among them: 144 students of the 4th-6th year of the medical faculty and the ...
V.V. Ogorenko, A.Ye. Nikolenko, T.Y. Shusterman, V.O. Kokashynskyi   +3 more
doaj   +1 more source

A novel multi-modal depression detection approach based on mobile crowd sensing and task-based mechanisms [PDF]

, 2022
Ravi Prasad Thati, Abhishek Singh Dhadwal, Praveen Kumar, P Sainaba   +3 more
openalex   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A scoping review of integrated arts therapies and neuroscience research

Frontiers in Psychology
IntroductionThis article provided a scoping review of the current state of the field for integrated arts therapies and neuroscience research. The main arts therapies modalities included in this review were: of arts therapies (i.e., drawing, painting ...
Rebecca Bokoch, Noah Hass-Cohen, April Espinoza, Tyler O’Reilly, Elad Levi   +4 more
doaj   +1 more source

Modal Predicates

The Australasian Journal of Logic, 2004
Despite the wide acceptance of standard modal logic, there has always been a temptation to think that ordinary modal discourse may be correctly analyzed and adequately represented in terms of predicates rather than in terms of operators. The aim of the formal model outlined in this paper is to capture what I take to be the only plausible sense in which
openaire   +4 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Insights into educational attainment: Maya City Grade 12 National Examination outcomes

Cogent Education
This research delves into the educational landscape in Maya City Secondary Schools, focusing on the outcomes of the Grade 12 National Examination through a mixed-method case study approach.
Chala Mosisa, Yilfashewa Seyoum Mekuria, Bayisa Eshetu   +2 more
doaj   +1 more source