Results 81 to 90 of about 1,618,868 (330)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The art of governing local education markets – municipalities and school choice in Finland
Education Inquiry, 2019 Since the 1980s, numerous education reforms in Europe and beyond have sought to dismantle centralised bureaucracies and replace them with devolved systems of schooling that emphasise parental choice and competition between diversified types of schools ...
Janne Varjo, Mira Kalalahti
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Geometric Cross-Modal Comparison of Heterogeneous Sensor Data
, 2017 In this work, we address the problem of cross-modal comparison of aerial data streams. A variety of simulated automobile trajectories are sensed using two different modalities: full-motion video, and radio-frequency (RF) signals received by detectors at ...
Bendich, Paul +6 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
MODAL: A multilingual corpus annotated for modality [PDF]
, 2017 We have produced a corpus annotated for modality which amounts to approximately 20,000 words in English, French, and Italian. The annotation scheme is based on the notion of epistemic construction and virtually languageindependent. The annotation is rigorously evaluated by means of a newly developed strategy based on the alignment of the entire ...
Nissim, Malvina, Pietrandrea, Paola
openaire +3 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
مجلة الآداب و العلوم الإجتماعية, 2019 Le constat que l’on pourrait se faire est que l’étudiant de langue étrangère, le FLE en particulier, est parfois dans l’incapacité d’analyser un discours produit en situation réelle, sans recourir à des reformulations du même discours.
Mohammed Mekhnache, Karima Zerouali
doaj
Executive Power: Rethinking the Modalities of Control [PDF]
, 2018 The Honorable Sundaresh Menon, Chief Justice of the Supreme Court of Singapore, delivered the 2018-2019 Bernstein Lecture in Comparative Law titled Executive Power: Rethinking the Modalities of Control.
Menon, Sundaresh
core +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source