Results 41 to 50 of about 269,662 (318)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Comprehensive Study on Deep Learning-Based 3D Hand Pose Estimation Methods

Applied Sciences, 2020
The field of 3D hand pose estimation has been gaining a lot of attention recently, due to its significance in several applications that require human-computer interaction (HCI).
Theocharis Chatzis, Andreas Stergioulas, Dimitrios Konstantinidis, Kosmas Dimitropoulos, Petros Daras   +4 more
doaj   +1 more source

A Framework for Audiovisual Dialog-based Human Computer Interaction

, 2014
In this paper, we describe a framework for audiovisual human computer interaction using a PC. The architecture of our system is based on recognized speech from both audio and visual information, and a dialog system that is capable of deriving the user's ...
Georgios Galatas, F. Makedon
semanticscholar   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

A Multimodal Affective Interaction Architecture Integrating BERT-Based Semantic Understanding and VITS-Based Emotional Speech Synthesis

Algorithms
Addressing the issues of coarse emotional representation, low cross-modal alignment efficiency, and insufficient real-time response capabilities in current human–computer emotional language interaction, this paper proposes an affective interaction ...
Yanhong Yuan, Shuangsheng Duo, Xuming Tong, Yapeng Wang   +3 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A Bimodal Emotion Recognition Approach through the Fusion of Electroencephalography and Facial Sequences

Diagnostics, 2023
In recent years, human–computer interaction (HCI) systems have become increasingly popular. Some of these systems demand particular approaches for discriminating actual emotions through the use of better multimodal methods. In this work, a deep canonical
Farah Muhammad, Muhammad Hussain, Hatim Aboalsamh   +2 more
doaj   +1 more source

Multi-Modal Trip Hazard Affordance Detection On Construction Sites

, 2017
Trip hazards are a significant contributor to accidents on construction and manufacturing sites, where over a third of Australian workplace injuries occur [1].
McMahon, Sean, Milford, Michael, Sünderhauf, Niko, Upcroft, Ben   +3 more
core   +2 more sources

Self-Supervised Vision-Based Detection of the Active Speaker as Support for Socially-Aware Language Acquisition [PDF]

, 2019
This paper presents a self-supervised method for visual detection of the active speaker in a multi-person spoken interaction scenario. Active speaker detection is a fundamental prerequisite for any artificial cognitive system attempting to acquire ...
Beskow, Jonas, Salvi, Giampiero, Stefanov, Kalin   +2 more
core   +2 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source