Results 41 to 50 of about 42,678 (260)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

High Power and Large-Energy Pulse Generation in an Erbium-Doped Fiber Laser by a Ferromagnetic Insulator-Cr₂Si₂Te₆ Saturable Absorber

Nanomaterials, 2022
Large-energy mode-locked fiber lasers are extensively studied due to their indispensable use in various fields and applications. Recently, ferromagnetic insulators have attracted tremendous research interest in ultra-fast photonics because of their ...
Zhifeng Hong, Xiwen Jiang, Meixia Zhang, Huanian Zhang, Xiaojuan Liu   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Optimization of Output Characteristics in Figure-9 Mode-Locked Fiber Laser Based on Black Phosphorus Assistance

Photonics
Utilizing the nonlinear effects of black phosphorus (BP), the self-starting threshold and noise performance were optimized in a figure-9 mode-locked fiber laser configuration.
Peiyuan Xiao, Lu Sui, Wanzhuo Ma, Renshun Pan, Huilin Jiang   +4 more
doaj   +1 more source

860 femtoseconds mode-locked fiber laser by Gallium co-doped erbium fiber (Ga-EDF)

Results in Physics, 2019
We proposed and demonstrated a high power mode-locked fiber laser using a new type of gain medium which is called as Erbium Gallium co-doped fiber (Ga-EDF). The mode-locking mechanism is enabled by a graphene-based saturable absorber, which is fabricated
N.A. Zazali, A.A. Latif, K.Y. Lau, M.A. Mahdi, F.D. Muhammad, Z. Yusoff, H.A. Abdul-Rashid, N.M. Radzi, N. Tamchek, M.H. Abu Bakar   +9 more
doaj   +1 more source

Dual-wavelength dispersion-managed soliton all-fiber mode-locked laser based on birefringence-filtered nonlinear polarization evolution

Results in Optics, 2022
Single-cavity dual-comb mode-locked lasers, an emerging dual-comb technology, can generate two sets of pulse sequences with excellent mutual coherence, thus eliminating the need for complex active noise reduction systems. We report the generation of dual-
Shuang Niu, Runmin Liu, Defeng Zou, Youjian Song, Minglie Hu   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Mode-locked multichromatic x rays in a seeded free-electron laser for single-shot x-ray spectroscopy

Physical Review Special Topics. Accelerators and Beams, 2012
We present the promise of generating gigawatt mode-locked multichromatic x rays in a seeded free-electron laser (FEL). We show that, by using a laser to imprint periodic modulation in electron beam phase space, a single-frequency coherent seed can be ...
Dao Xiang, Yuantao Ding, Tor Raubenheimer, Juhao Wu   +3 more
doaj   +1 more source