Results 11 to 20 of about 38,598 (216)

An exploration of the preferences and mode choice behavior between autonomous demand-responsive transit and traditional buses

International Journal of Transportation Science and Technology, 2023
With the advancement in autonomous driving techniques, autonomous demand-responsive transit (ADRT) is a newly emerging sustainable transport mode for the future, which will provide more flexible services to public users. ADRT offers benefits such as flexible stops and routes and comfortable seats, but it also involves risks due to the vehicles being ...
Hao Li, Zhicheng Jin, Hang Cui, Huizhao Tu   +3 more
openalex   +3 more sources

Critical Demand Density Thresholds for Public Transit Mode Transition: A Study on Fixed-Route and Demand-Responsive Systems Under Financial Subsidies

IEEE Access
Yucong Zu, Mingfei Wang, Li Li, Meng Li, Meng Zhang   +4 more
openalex   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Online Predictive Optimization Framework for Stochastic Demand-Responsive Transit Services

, 2019
This study develops an online predictive optimization framework for dynamically operating a transit service in an area of crowd movements. The proposed framework integrates demand prediction and supply optimization to periodically redesign the service ...
Dauwels, Justin, Jiang, Yu, Lee, Kelvin, Peled, Inon, Pereira, Francisco C.   +4 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Performance Measures to Assess Resiliency and Efficiency of Transit Systems [PDF]

, 2017
Transit agencies are interested in assessing the short-, mid-, and long-term performance of infrastructure with the objective of enhancing resiliency and efficiency.
Bartin, Bekir, Deka, Devajyoti, El-Awar, Ayman, Lou, Peng, Morgul, Ender Faruk, Mudigonda, Sandeep, Na, Chaekuk, Nassif, Hani, Zhu, Yuan, Özbay, Kaan   +9 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source