Results 61 to 70 of about 70,460 (284)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Spatial Visual Imagery (SVI)-Based Electroencephalograph Discrimination for Natural CAD Manipulation

Sensors
With the increasing demand for natural interactions, people have realized that an intuitive Computer-Aided Design (CAD) interaction mode can reduce the complexity of CAD operation and improve the design experience.
Beining Cao, Hongwei Niu, Jia Hao, Xiaonan Yang, Zinian Ye   +4 more
doaj   +1 more source

A compact control system to achieve stable voltage and low jitter trigger for repetitive intense electron-beam accelerator based on resonant charging

AIP Advances, 2017
A compact control system based on Delphi and Field Programmable Gate Array(FPGA) is developed for a repetitive intense electron-beam accelerator(IEBA), whose output power is 10GW and pulse duration is 160ns.
Yongfeng Qiu, Jinliang Liu, Jianhua Yang, Xinbing Cheng, Xiao Yang   +4 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

MELGYM: A dynamic control interface for MELCOR simulations

SoftwareX
MELCOR is a computer code for the simulation and safety analysis of nuclear facilities, comprising several modules for the calculation of thermal–hydraulic phenomena and aerosol physics.
Antonio Manjavacas, Juan Gómez-Romero, Damien Ernst, Manuel A. Vázquez-Barroso, Francisco Martín-Fuertes   +4 more
doaj   +1 more source

Experimental studies on engine test system based on virtual instrument technology

浙江大学学报. 农业与生命科学版, 2003
Virtual Instrumentation (VI) is becoming a popular tool in measurement, test and automation as a result of rapid development of computer technology. In this paper, a engine test experimental system comprised of computer, DAQ Card PCI-6024E board, and ...
YE Sheng, HE Yong, XU Xiao-ming
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

DESIGN AND RESEARCH OF INTELLIGENT CONTROL SYSTEM FOR BELT CONVEYOR

Jixie qiangdu, 2019
According to the working process and fault characteristics of belt conveyor, a safe and reliable intelligent control system solution is proposed. The solution consists of centralized control system and field control system.
WANG JiDong, SUN JianYan, HU MeiLing
doaj  

Test of a cubic spline interface for physical processes with a 1-D third-order spectral element model

Tellus: Series A, Dynamic Meteorology and Oceanography, 2019
A common way to introduce physical processes into numerical models of the atmosphere is to call the parameterization at every grid point. This can lead to considerable errors.
J. Steppeler, J. Li, F. Fang, J. Zhu
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source