Results 81 to 90 of about 928,321 (341)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Principle of On-line Monitoring System of Mine Main Ventilator and Its Applicatio

Gong-kuang zidonghua, 2011
The paper analyzed design principle of software and hardware of on-line monitoring system of mine main ventilator and introduced concrete application of the system in Junde Coal Mine from points of sensor selection, communication mode, monitoring ...
MIAO Yu-song, SONG Hai-jun
doaj  

Cybersecurity in Brain-Computer Interfaces: RFID-based design-theoretical framework

Informatics in Medicine Unlocked, 2021
Brain Computer Interface BCI is a real-time communication system that connects the brain and external devices. The BCI system can directly convert the information sent by the brain into commands that can drive external devices and replace human limbs or ...
Shams Ajrawi, Ramesh Rao, Mahasweta Sarkar   +2 more
doaj  

Virtual Delamination Testing through Non-Linear Multi-Scale Computational Methods: Some Recent Progress [PDF]

, 2012
This paper deals with the parallel simulation of delamination problems at the meso-scale by means of multi-scale methods, the aim being the Virtual Delamination Testing of Composite parts.
Allix, Olivier, Gosselet, Pierre, Kerfriden, Pierre, Saavedra, Karin   +3 more
core   +5 more sources

RESEARCH OF MULTICHANNEL MODES OF THE NETWORK INTERFACE OF MODULAR COMPUTING SYSTEMS

International scientific and technical conference Information technologies in metallurgy and machine building, 2022
This paper considers the so-called "blade" server solutions of multiprocessor computing systems, where several same-type mother modules are installed in one enclosure. The main feature of the clustered system, which is considered in this paper, is that the data interchange among computing nodes is carried out in a separate network, which operates at ...
openaire   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Virtual Assisted Self Interviewing (VASI): An Expansion of Survey Data Collection Methods to the Virtual Worlds by Means of VDCI [PDF]

Changes in communication technology have allowed for the expansion of data collection modes in survey research. The proliferation of the computer has allowed the creation of web and computer assisted auto-interview data collection modes.
Edward Castronova, Gert G. Wagner, Mark W. Bell   +2 more
core   +3 more sources

DEVELOPMENT OF METHODS AND MEANS OF COMPUTER SIMULATION FOR STUDYING ARC FURNACE ELECTRIC MODES

Electrical engineering & Electromechanics, 2018
Goal. The purpose of the article is the creation of a three-phase instantaneous coordinates Simulink computer model of the power supply and automatic coordinates control system (ACS) of the DSP-200 type arc furnace electric mode (EM).
O. Y. Lozynskyi, Y. S. Paranchuk, R. Y. Paranchuk, F. D. Matico   +3 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Spatial Visual Imagery (SVI)-Based Electroencephalograph Discrimination for Natural CAD Manipulation

Sensors
With the increasing demand for natural interactions, people have realized that an intuitive Computer-Aided Design (CAD) interaction mode can reduce the complexity of CAD operation and improve the design experience.
Beining Cao, Hongwei Niu, Jia Hao, Xiaonan Yang, Zinian Ye   +4 more
doaj   +1 more source