Results 141 to 150 of about 3,293,063 (304)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mode Coupling at around M-Point in PZT. [PDF]

Materials (Basel), 2021
Vakhrushev S, Filimonov A, Petroukhno K, Rudskoy A, Udovenko S, Leontyev I, Bosak A.   +6 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Applicability of the Generalized Stokes-Einstein Equation of Mode-Coupling Theory to Near-Critical Polyelectrolyte Complex Solutions. [PDF]

ACS Macro Lett, 2023
Ma Y, Hudson SD, Salipante PF, Douglas JF, Prabhu VM.   +4 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Exciton-dielectric mode coupling in MoS₂ nanoflakes visualized by cathodoluminescence. [PDF]

Nanophotonics, 2022
Vu DT, Matthaiakakis N, Saito H, Sannomiya T.   +3 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Revisit two-mode couplings of the ablative Rayleigh–Taylor instability in inertial confinement fusion

Nuclear Fusion
Two-dimensional two-mode couplings of the ablative Rayleigh–Taylor instability (ARTI) under inertial-confinement-fusion (ICF) relevant parameters are revisited via numerical simulations, with a focus on the regimes where the wavenumbers of the initial ...
Xian Jiang, Shenming Xu, Dehua Zhang, Tao Tao, Jingfei Xin, Rui Yan, Hang Ding, Jian Zheng   +7 more
doaj   +1 more source

Mode coupling bi-stability and spectral broadening in buckled carbon nanotube mechanical resonators. [PDF]

Nat Commun, 2022
Rechnitz S, Tabachnik T, Shlafman M, Shlafman S, Yaish YE.   +4 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source